CYP1A2

シトクロムP450 1A2は、略称CYP1A2と呼ばれ、シトクロムP450混合機能オキシダーゼのメンバーのひとつであり、人体において生体異物の代謝に関与している。

CYP1A2
PDBに登録されている構造
PDBオルソログ検索: RCSB PDBe PDBj
識別子
記号CYP1A2, CP12, P3-450, P450(PA), cytochrome P450 family 1 subfamily A member 2, Cytochrome P450 1A2, CYPIA2
外部IDOMIM: 124060 MGI: 88589 HomoloGene: 68082 GeneCards: CYP1A2
遺伝子の位置 (ヒト)
染色体15番染色体 (ヒト)[1]
バンドデータ無し開始点74,748,845 bp[1]
終点74,756,607 bp[1]
RNA発現パターン


さらなる参照発現データ
オルソログ
ヒトマウス
Entrez

1544

13077

Ensembl

ENSG00000140505

ENSMUSG00000032310

UniProt

P05177

P00186

RefSeq
(mRNA)

NM_000761

NM_009993

RefSeq
(タンパク質)

NP_000752

NP_034123

場所
(UCSC)
Chr 15: 74.75 – 74.76 MbChr 15: 57.68 – 57.68 Mb
PubMed検索[3][4]
ウィキデータ
閲覧/編集 ヒト閲覧/編集 マウス

CYP1A2の発現は、様々な栄養成分によって誘導されるとみなされている[5]

CYP1A2のリガンド

CYP1A2の選択的な基質誘導剤及び阻害剤の一覧を以下の表に示す。

基質阻害剤誘導剤
よく言及される [6]:

:

強力 [7]:

詳細不明:

よく言及される[6]:

:

薬物相互作用

様々な薬剤や食品との薬物相互作用があり、薬の作用が強まったり弱まったりする事が報告されている[9][10]。例えば喫煙は CYP1A2 で代謝される薬の作用を弱める[10][11]

脚注

  1. GRCh38: Ensembl release 89: ENSG00000140505 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032310 - Ensembl, May 2017
  3. Human PubMed Reference:
  4. Mouse PubMed Reference:
  5. Fontana R, Lown K, Paine M, Fortlage L, Santella R, Felton J, Knize M, Greenberg A, Watkins P (1999). “Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers”. Gastroenterology 117 (1): 89–98. doi:10.1016/S0016-5085(99)70554-8. PMID 10381914.
  6. Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
  7. Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)
  8. Edwards DJ, Bernier SM (1996). “Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man”. Life Sciences 59 (13): 1025–1030. doi:10.1016/0024-3205(96)00417-1. PMID 8485024.
  9. 平田睦子、齋藤充生、浦野勉 ほか、日本の医薬品添付文書におけるCYPに関する情報の解析研究 Bull. Natl. Inst. Health Sci., 123, 12-18 (2005) (PDF) ,国立医薬品食品衛生研究所報告第123号第一部
  10. 上野雅代、前原加奈子、吉住亜紀子 ほか、「入院患者への薬剤師による禁煙支援」 『医療薬学』 2008年 34巻 9号 p.882-890, doi:10.5649/jjphcs.34.882
  11. インデラルで指導された意外な嗜好品とは? 日経 DIオンライン 記事:2017年5月17日

参考文献

  • Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). “Molecular genetics of the human cytochrome P450 monooxygenase superfamily.”. Xenobiotica 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157.
  • Landi MT, Sinha R, Lang NP, Kadlubar FF (1999). “Human cytochrome P4501A2.”. IARC Sci. Publ. (148): 173–95. PMID 10493258.
  • Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). “Comparison of cytochrome P450 (CYP)genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.”. Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
  • Ikeya K, Jaiswal AK, Owens RA, et al. (1990). “Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.”. Mol. Endocrinol. 3 (9): 1399–408. PMID 2575218.
  • Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF (1989). “Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.”. Proc. Natl. Acad. Sci. U.S.A. 86 (20): 7696–700. doi:10.1073/pnas.86.20.7696. PMID 2813353.
  • Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH (1986). “Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.”. DNA 4 (5): 395–400. PMID 3000715.
  • Quattrochi LC, Pendurthi UR, Okino ST, et al. (1986). “Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.”. Proc. Natl. Acad. Sci. U.S.A. 83 (18): 6731–5. doi:10.1073/pnas.83.18.6731. PMID 3462722.
  • Wrighton SA, Campanile C, Thomas PE, et al. (1986). “Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.”. Mol. Pharmacol. 29 (4): 405–10. PMID 3517618.
  • Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ (1988). “Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15.”. J. Exp. Pathol. 3 (1): 1–17. PMID 3681487.
  • Jaiswal AK, Nebert DW, Gonzalez FJ (1986). “Human P3(450): cDNA and complete amino acid sequence.”. Nucleic Acids Res. 14 (16): 6773–4. doi:10.1093/nar/14.16.6773. PMID 3755823.
  • Eugster HP, Probst M, Würgler FE, Sengstag C (1993). “Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.”. Drug Metab. Dispos. 21 (1): 43–9. PMID 8095225.
  • Schweikl H, Taylor JA, Kitareewan S, et al. (1994). “Expression of CYP1A1 and CYP1A2 genes in human liver.”. Pharmacogenetics 3 (5): 239–49. doi:10.1097/00008571-199310000-00003. PMID 8287062.
  • Yamazaki H, Inoue K, Mimura M, et al. (1996). “7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes.”. Biochem. Pharmacol. 51 (3): 313–9. doi:10.1016/0006-2952(95)02178-7. PMID 8573198.
  • Hakkola J, Raunio H, Purkunen R, et al. (1996). “Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy.”. Biochem. Pharmacol. 52 (2): 379–83. doi:10.1016/0006-2952(96)00216-X. PMID 8694864.
  • Guengerich FP, Johnson WW (1998). “Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems.”. Biochemistry 36 (48): 14741–50. doi:10.1021/bi9719399. PMID 9398194.
  • Wacke R, Kirchner A, Prall F, et al. (1998). “Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis.”. Pancreas 16 (4): 521–8. doi:10.1097/00006676-199805000-00011. PMID 9598815.
  • Macé K, Bowman ED, Vautravers P, et al. (1998). “Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues.”. Eur. J. Cancer 34 (6): 914–20. doi:10.1016/S0959-8049(98)00034-3. PMID 9797707.
  • Huang JD, Guo WC, Lai MD, et al. (1999). “Detection of a novel cytochrome P-450 1A2 polymorphism (F21L)in Chinese.”. Drug Metab. Dispos. 27 (1): 98–101. PMID 9884316.
  • Tatemichi M, Nomura S, Ogura T, et al. (1999). “Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with intestinal metaplasia.”. Cancer Res. 59 (16): 3893–8. PMID 10463577.

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