Metabolite

In biochemistry, a metabolite is an intermediate or end product of metabolism.[1] The term metabolite is usually used for small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and pheromones).

A primary metabolite is directly involved in normal "growth", development, and reproduction. Ethylene exemplifies a primary metabolite produced large-scale by industrial microbiology.

A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments such as resins and terpenes etc.

Some antibiotics use primary metabolites as precursors, such as actinomycin, which is created from the primary metabolite tryptophan. Some sugars are metabolites, such as fructose or glucose, which are both present in the metabolic pathways.

Examples of primary metabolites produced by industrial microbiology include:[2]

ClassExample
AlcoholEthanol
Amino acidsGlutamic acid, aspartic acid
Nucleotides5' guanylic acid
AntioxidantsIsoascorbic acid
Organic acidsAcetic acid, lactic acid
PolyolsGlycerol
VitaminsB2

The metabolome forms a large network of metabolic reactions, where outputs from one enzymatic chemical reaction are inputs to other chemical reactions.

Metabolites from chemical compounds, whether inherent or pharmaceutical, form as part of the natural biochemical process of degrading and eliminating the compounds.[3] The rate of degradation of a compound is an important determinant of the duration and intensity of its action. Understanding how pharmaceutical compounds are metabolized and the potential side effects of their metabolites is an important part of drug discovery.[4]

See also

  • Antimetabolite
  • Intermediary metabolism, also called intermediate metabolism
  • Metabolic control analysis
  • Metabolomics, the study of global metabolite profiles in a system (cell, tissue, or organism) under a given set of conditions
  • Metabolic pathway
  • Volatile Organic Compounds

References

  1. Venes, Donald, ed. (1940). Taber's Cyclopedic Medical Dictionary (23 ed.). Philadelphia: F.A. Davis (published 2017). p. 1510. ISBN 9780803659407. Retrieved 16 March 2020. metabolite [...] Any product of metabolism.
  2. Demain, Arnold L. (December 1980). "Microbial production of primary metabolites". Naturwissenschaften. 67 (12): 582–587. doi:10.1007/BF00396537. PMID 7231563. S2CID 21590956.
  3. Harris, Edward D. "Biochemical Facts behind the Definition and Properties of Metabolites" (PDF). FDA.gov. United States Food and Drug Administration. Retrieved 28 April 2017.
  4. Obach, R. Scott; Esbenshade, Timothy A. (April 2013). "Pharmacologically Active Drug Metabolites: Impact on Drug Discovery and Pharmacotherapy". Pharmacological Reviews. 65 (2): 578–640. doi:10.1124/pr.111.005439. PMID 23406671. S2CID 720243.
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