Torsemide

General

Administration

  • Type: Loop diuretic
  • Dosage Forms:
  • Routes of Administration: IV, PO
  • Common Trade Names: Demadex

Adult Dosing

40mg furosemide = 20mg torsemide = 1mg bumetanide = 50mg Ethacrynic acid

  • 5-200 mg PO or IV daily. Titrate to effect by doubling dose

Pediatric Dosing

Safety/efficacy not established

Special Populations

  • Pregnancy Rating: B
  • Lactation risk: Infant risk cannot be ruled out

Renal dosing: no adjustment Hepatic dosing: no adjustment

Contraindications

  • Allergy to class/drug
  • Anuria

Adverse Reactions

Serious

  • Ventricular tachycardia
  • SJS/TEN
  • Ototoxicity

Common

  • Polyuria
  • Rhinitis

Pharmacology

  • Half-life: 2-4 hours
  • Metabolism:P450
  • Excretion: Renal

Mechanism of Action

  • Loop diuretic: interferes with Na/K/Cl cotransport system, inhibiting reabsorption of Na/Cl in the ascending limb of the loop of Henle

See Also

References

  1. Asare K. Management of Loop Diuretic Resistance in the Intensive Care Unit. Am J Health Syst Pharm. 2009;66(18):1635-1640.
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