Pioglitazone

Administration

  • Type: Diabetes medication
  • Dosage Forms: 15 mg, 30 mg, 45 mg
  • Routes of Administration: PO
  • Common Trade Names: Actos

Adult Dosing

  • 15-45 mg PO qd
  • Max: 45 mg/day

Pediatric Dosing

  • >15-30 mg PO qd
  • Start with 15 mg PO qd
  • Max: 45 mg/day
  • Give with metformin

Special Populations

  • Pregnancy Rating: C
  • Lactation risk: No recommended
  • Renal Dosing: no adjustment
  • Hepatic Dosing: no adjustment

Contraindications

  • Allergy to class/drug
  • Pediatric patients <15 yo
  • Type 1 diabetes
  • DKA
  • Active bladder cancer
  • CHF (symptomatic; NYHA Class III-IV)

Caution

  • CHF (NYHA Class I-II)
  • CHF Risk
  • Edema
  • Hepatic impairment
  • Bladder cancer history
  • Premenopausal anovulatory patients

Adverse Reactions

Serious

  • CHF
  • Hepatotoxicity
  • Diabetic macular edema
  • Bladder cancer risk
  • Fractures (females)

Common

  • URI
  • Headache
  • Myalgia
  • Weight gain
  • Edema
  • Fluid retention
  • Flatulence
  • Anemia
  • Ovulation induction

Pharmacology

  • Half-life: 3-7 hrs; 16-24 hrs (metabolites)
  • Metabolism: Liver (CYP450)
  • Excretion: Urine; bile

Mechanism of Action

  • Increases insulin sensitivity

Comments


See Also

References

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