Losartan

Administration

  • Type: Antihypertensive, ARB
  • Dosage Forms: Tablet; 25mg, 50mg, 100mg
  • Routes of Administration: oral
  • Common Trade Names: Cozaar

Adult Dosing

Hypertension

  • 25-150mg PO daily

Pediatric Dosing

  • 0.1 to 1.4 mg/kg daily

Special Populations

  • Pregnancy Rating: D
  • Lactation risk: Infant risk cannot be ruled out
  • Renal dosing: no adjustment
  • Hepatic dosing: starting dose 25mg daily

Contraindications

  • Allergy to class/drug
  • Concomitant use with aliskiren in diabetes

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 2-6 hours
  • Metabolism: Hepatic;P450 CYP2C9 and CYP3A4
  • Excretion: Fecal, renal

Mechanism of Action

  • Reversible angiotensin II inhibitor

See Also

  • Hypertension

References

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