Esophageal candidiasis

Background

  • Most commonly seen in HIV patients with CD4 count < 100 (AIDS-defining illness) or chronic inhaled glucocorticoid use

Clinical Features[1]

  • Odynophagia
  • Dysphagia
  • Retrosternal pain
  • Nausea/vomiting

Differential Diagnosis

Esophagitis

Evaluation

  • Thick, white, linear esophageal plaques on endoscopy

Management

  • Fluconazole 400mg PO loading dose, followed by 200mg PO Qdaily x 2 weeks
  • Itraconazole 200mg PO Qdaily for 2 weeks
    • has more nausea side-effects and drug interactions compared to fluconazole

References

  1. Kauffmann CA. Overview of Candida Infections. UptoDate. 2016.
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