Cyclobenzaprine

Toxicity

Administration

  • Type: muscle relaxant
  • Dosage Forms:
  • Routes of Administration: Oral
  • Common Trade Names: Flexeril

Adult Dosing

  • 5-10mg PO 1-3 times per day

Pediatric Dosing

  • >15 y/o
  • 5-10 mg TID

Special Populations

  • Pregnancy Rating: B
  • Lactation risk: infant risk cannot be ruled out

Renal Dosing

  • Adult:
  • Pediatric:

Hepatic Dosing

  • Adult: Titrate slowly
  • Pediatric:

Contraindications

  • Allergy to class/drug
  • MAOI use, concomitantly or within 14 days
  • Heart block or other serious arrhythmias, CHF

Adverse Reactions

Serious

  • Neuroleptic malignant syndrome
  • Serotonin syndrome
  • Stroke
  • Dysrhythmias, heart block
  • Bone marrow depression
  • Hepatitis

Common

  • Somnolence, dizziness
  • Nausea, constipation

Pharmacology

  • Half-life: ~18h for immediate release, 32h for extended release
  • Metabolism: hepatic
  • Excretion: Urine

Mechanism of Action

  • Acts on CNS to reduce tonic somatic motor activity

References

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