This page is for the drug cocaine; for clinical effects see cocaine toxicity


  • Type: Local anesthetic
  • Dosage Forms: 4% solution; 10% solution
  • Routes of Administration: Topical
  • Common Trade Names: Cocaine

Adult Dosing

  • 1-3 mg/kg, max dose of 200 mg
    • Some literature suggests maximum dose of 100 mg
    • Ideally use lowest effective dose

Pediatric Dosing

  • 1 mg/kg
    • No clear safe dose established

Special Populations

Renal Dosing

  • Adult: N/A
  • Pediatric: N/A

Hepatic Dosing

  • Adult: N/A
  • Pediatric: N/A


  • Allergy to class/drug

Adverse Reactions


  • Half-life: 50 to 75 minutes (5.5 hours benzoylecgonine metabolite)
  • Metabolism: Plasma cholinesterase; liver
  • Excretion: Renal

Mechanism of Action

  • Blocks reuptake of serotonin, dopamine and norepinephrine
  • Anesthetic effects achieved through sodium channel blockade


See Also



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