Calcium chloride

See critical care quick reference for drug doses by weight.


  • Type: Mineral, Antidote
  • Dosage Forms: injectable solution
  • Dosage Strengths: 100 mg/mL
  • Routes of Administration: IV
  • Common Trade Names:

Adult Dosing

  • Hypocalcemia (emergent): 500-1000 mg IV over 5-10 minutes, repeat as needed
  • Arrhythmias (emergent): 500-1000 mg IV over 5-10 minutes, repeat as needed
  • Hypermagnesemia: 500-1000 mg IV over 2-5 minutes, repeat if CNS depression persists
  • Calcium channel blocker toxicity: 1-2 g IV infused over 10-20 min; repeat every 20 minutes PRN up to 5 doses
  • Beta-blocker toxicity (Refractory to glucagon/vasopressors): 1g IV bolus
  • Hyperkalemia: 1g IV
  • Cardiac Arrest: 1g IV (not recommended for routine use[1])

Pediatric Dosing

See critical care quick reference for drug doses by weight.

Special Populations

  • Pregnancy Rating: C
  • Lactation: Infant risk cannot be ruled out
  • Renal Dosing: base dosing on serum Ca if CrCl <25, may need reduced dose if on HD
  • Hepatic dosing: No adjustment


  • Allergy to class/drug
  • Current use of ceftriaxone sodium injection in neonates
  • Ventricular fibrillation
  • Do NOT administer for IM or subq
  • Administer through central venous access except in cases of cardiac arrest
    • High risk of extravasation and tissue necrosis

Adverse Reactions


  • Vasodilation
  • Tissue necrosis (if extravasated)


  • Burning sensation


  • Half-life:
  • Metabolism:
  • Excretion: Renal, fecal

Mechanism of Action

  • Cofoactor in many enzymatic reactions, essential for neurotransmission, muscle contraction, and many signal transduction pathways

See Also


  1. Neumar RW, Otto CW, Link MS, et al. Part 8: adult advanced cardiovascular life support: 2010 American Heart Association Guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2010;122(18 Suppl 3):729-767. doi: 10.1161/CIRCULATIONAHA.110.970988. [PubMed 20956224]
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