• Type: Loop diuretic
  • Dosage Forms: injectable solution, tablet
  • Dosage Strengths: injectable solution: 0.25mg/mL; tablet: 0.5, 1, 2mg
  • Routes of Administration: IV, PO
  • Common Trade Names: Bumex, Burinex

Adult Dosing

40mg furosemide = 20mg torsemide = 1mg bumetanide = 50 mg ethacrynic acid

  • 0.5 to 1 mg IV or 0.5-2mg PO. If inadequate response, repeat q2-3 hours to maximum of 10 mg per day

Pediatric Dosing

Safety/efficacy not established

Special Populations

  • Pregnancy Rating: C
  • Lactation risk: Infant risk cannot be ruled out
  • Renal dosing: no adjustment
  • Hepatic dosing: use lowest dose necessary, titrate slowly


  • Allergy to class/drug
  • Anuria
  • Hepatic coma
  • Severe electrolyte depletion

Adverse Reactions


  • SJS
  • Encephalopathy
  • Thrombocytopenia


  • Hypotenchion
  • Hypouricemia, hypokalemia, hypochloremia
  • Cramps
  • Dizziness, headache
  • Nausea


  • Rapid onset
  • Half-life: 1-6 hours
  • Metabolism: Partially metabolized in liver
  • Excretion: Mostly renal

Mechanism of Action

  • Inhibits the reabsorption of sodium and chloride in the ascending limb of the loop of Henle

See Also


  1. Asare K. Management of Loop Diuretic Resistance in the Intensive Care Unit. Am J Health Syst Pharm. 2009;66(18):1635-1640.
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