- Affects 20% of the normal population
- Unclear etiology. Common triggers: stress, hormonal changes, smoking, certain food such as coffee, chocolate.
- Resolve spontaneously in 10-14d
- Involves the nonkeratinized epithelium (especially labial and buccal mucosa)
- Begins as erythematous macule that ulcerates and forms a central fibropurulent eschar
- Lesions measure from 2-3mm to several cm in diameter
- Clinical diagnosis
- Tilliss TS, Mcdowell JD. Differential diagnosis: is it herpes or aphthous?. J Contemp Dent Pract. 2002;3(1):1-15.