- Type: Antifungal
- Dosage Forms: powder for injection
- Dosage Strengths: 50mg/vial
- Routes of Administration: IV
- Common Trade Names: AmBisome, Fungizone "ampho-terrible"
Dosing is NOT interchangeable between different formulations of amphotericin B due to significant variations in pharmacokinetics. Call your institution's pharmacy (or ID) if unsure about correct dose.
- Pregnancy Rating: B
- Lactation risk: Infant risk cannot be ruled out
- Allergy to class/drug
- Nephrotoxicity/renal failure, hemorrhagic cystitis
- Cardiac arrest
- Hypokalemia, hypomagnesemia, hyperglycemia (check BMP at least daily)
- Nausea/vomiting, diarrhea
- Half-life: Depends on formulation, 1-14 days
- Metabolism: unknown
- Excretion: urine
Mechanism of Action
- Binds to ergosterol in fungal cell membranes→ intracellular contents leak out→ cell dies
Amphotericin B is an antifungal agent used to treat severe or disseminated fungal infections (e.g. invasive aspergillosis, cryptoccoccal meningitis, coccidioidomycosis, mucormycosis, fungemia in neutropenic patients). It comes in several formulations; conventional, cholesteryl sulfate complex, lipid complex, and liposomal. It is usually reserved for serious infection due to significant associated toxicities, though the newer formulations tend to be better tolerated.