• Type: Antipyretic
  • Dosage Forms: IV; PO; PR
  • Common Trade Names: Tylenol, Paracetamol

Adult Dosing


  • PO
    • Immediate-release
      • Regular strength: 650mg q4-6 hours
      • Extra strength: 1000mg q6 hours
    • Extended-release: 1300mg q8 hours
  • Rectal: 650mg q4-6 hours
  • IV:
    • <50 kg: 15mg/kg q6 hours or 12.5mg/kg q4 hours
    • ≥50 kg: 650mg q4 hours or 1000mg q6 hours
  • Maximum daily dose: 4g

Pediatric Dosing

  • 15mg/kg/dose q6 hours

Acetaminophen Pediatric Dosing Chart

Weight (kg) Weight (lbs) Age Dosage (mg)
3-46-110-3 mo40
5-712-174-11 mo80
8-1018-231-2 y120
11-1524-352-3 y160
16-2136-474-5 y240
22-2648-596-8 y320
27-3260-719-10 y400
33-4372-9511 y480
Dosage can be given q6hours

Special Populations

  • Pregnancy Rating: B
  • Lactation Risk Categories: safe
  • Renal Dosing
    • Adult: CrCl 10-50: give q6h, CrCl <10: give q8h
    • Pediatric: CrCl 10-50: give q6h, CrCl <10: give q8h
  • Hepatic Dosing
    • Adult: not defined
    • Pediatric: not defined


  • Allergy to class/drug

Adverse Reactions




  • When calculating maximum daily dose consider all sources of acetaminophen
  • Be careful that the dose in milligrams and milliliters is not confused


  • Half-life: 2-4 hour
  • Metabolism: Liver
  • Excretion: urine
  • Mechanism of Action:antipyretic effect via direct action on the hypothalamic heat-regulating center

See Also


  • Acephen (acetaminophen suppositories) [prescribing information]. South Plainfield, NJ: G&W Laboratories; April 2014.
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