Zinc-activated ion channel
|Aliases||ZACN, L2, LGICZ, LGICZ1, ZAC, ZAC1, Zinc-activated ion channel, zinc activated ion channel|
|External IDs||HomoloGene: 52296 GeneCards: ZACN|
|Location (UCSC)||Chr 17: 76.07 – 76.08 Mb||n/a|
Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes.
ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach. The endogenous ligand for ZAC is thought to be Zn2+, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.
- GRCh38: Ensembl release 89: ENSG00000186919 - Ensembl, May 2017
- "Human PubMed Reference:".
- Davies PA, Wang W, Hales TG, Kirkness EF (January 2003). "A novel class of ligand-gated ion channel is activated by Zn2+". The Journal of Biological Chemistry. 278 (2): 712–7. doi:10.1074/jbc.M208814200. PMID 12381728.
- Houtani T, Munemoto Y, Kase M, Sakuma S, Tsutsumi T, Sugimoto T (September 2005). "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochemical and Biophysical Research Communications. 335 (2): 277–85. doi:10.1016/j.bbrc.2005.07.079. PMID 16083862.