Clinical data
Drug class Nonsteroidal estrogen; Nuclear factor κB inhibitor
CAS Number
PubChem CID
Chemical and physical data
Formula C34H31F3N2O2
Molar mass 556.629 g/mol
3D model (JSmol)

WAY-204688, also known as SIM-688, is a synthetic nonsteroidal estrogen and nuclear factor κB (NF-κB) inhibitor which was originated by ArQule and Wyeth and was under development by Wyeth for the treatment of rheumatoid arthritis, non-specific inflammation, and sepsis but was never marketed.[1][2][3] It is a "pathway-selective" estrogen receptor (ER) ligand which inhibits NF-κB with an IC50 of 122 nM and with maximal inhibition relative to estradiol of 94%.[3][4] Inhibition of NF-κB by WAY-204688 appears to be dependent on agonism of the ERα, as it is reversed by the ERα antagonist fulvestrant, but is not dependent on the ERβ.[3][4] In contrast to the case of NF-κB inhibition, WAY-204688 produces only slight elevation of creatine kinase in vitro, a measure of classical estradiol effects.[3][4] It reached phase I clinical trials prior to the discontinuation of its development.[1]


  1. 1 2 https://adisinsight.springer.com/drugs/800022078
  2. Ivanenkov YA, Balakin KV, Lavrovsky Y (January 2011). "Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics". Mini Rev Med Chem. 11 (1): 55–78. doi:10.2174/138955711793564079. PMID 21034406.
  3. 1 2 3 4 Dodge, Jeffrey A.; Richardson, Timothy I. (2007). "Chapter 10 Novel Selective Estrogen Receptor Modulators (SERMs)". 42: 147–160. doi:10.1016/S0065-7743(07)42010-3. ISSN 0065-7743.
  4. 1 2 3 Opal SM, Palardy JE, Cristofaro P, Parejo N, Jhung JW, Keith JC, Chippari S, Caggiano TJ, Steffan RJ, Chadwick CC, Harnish DC (December 2005). "The activity of pathway-selective estrogen receptor ligands in experimental septic shock". Shock. 24 (6): 535–40. doi:10.1097/01.shk.0000183388.90895.cb. PMID 16317384.

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