Berenguer joined the Spanish Beisbol Network in 2002 as a statistician, engineer, pregame and postgame host, and play-by-play announcer. He had previously worked as a statistician for WEEI and in the Red Sox community relations office. In 2003, Berenguer became a full-time announcer upon the departure of Juan Oscar Baez. At 21, he was one of the youngest full-time broadcasters in the history of the major leagues. In May 2005, Berenguer became the lead announcer following the death of broadcast partner Juan Pedro Villamán. In 2009, Berenguer was one of five announcers used by the MLB Network to call the Caribbean Series.
Berenguer was treated for histiocytosis at the Jimmy Fund Clinic at Dana-Farber Cancer Institute from 1985-2001. He is a graduate of the Boston Latin Academy and Northeastern University. He was a member of Latin Academy's baseball, football and track teams. His uncle Juan Berenguer played in the major leagues from 1978-1992.
On November 12, 2010, NESN announced that due to the lack of chemistry with Jade McCarthy and the low ratings of the show, Uri Berenguer had been removed as co-host of NESN Daily.