RAD140

RAD140
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C20H16ClN5O2
Molar mass 393.83 g·mol−1
3D model (JSmol)

RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer, currently under development by Radius Health, Inc. (RDUS).[1][2][3][4]

See also

References

  1. Jayaraman, Anusha; Christensen, Amy; Moser, V. Alexandra; Vest, Rebekah S.; Miller, Chris P.; Hattersley, Gary; Pike, Christian J. (April 2014). "Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats". Endocrinology. 155 (4): 1398–1406. doi:10.1210/en.2013-1725. ISSN 0013-7227. PMC 3959610. PMID 24428527.
  2. Hamson, D. K.; Wainwright, S. R.; Taylor, J. R.; Jones, B. A.; Watson, N. V.; Galea, L. a. M. (September 2013). "Androgens Increase Survival of Adult-Born Neurons in the Dentate Gyrus by an Androgen Receptor-Dependent Mechanism in Male Rats". Endocrinology. 154 (9): 3294–3304. doi:10.1210/en.2013-1129. ISSN 0013-7227. PMID 23782943.
  3. Miller, Chris P.; Shomali, Maysoun; Lyttle, C. Richard; O’Dea, Louis St. L.; Herendeen, Hillary; Gallacher, Kyla; Paquin, Dottie; Compton, Dennis R.; Sahoo, Bishwabhusan; Kerrigan, Sean A.; Burge, Matthew S.; Nickels, Michael; Green, Jennifer L.; Katzenellenbogen, John A.; Tchesnokov, Alexei; Hattersley, Gary (February 2011). "Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140". ACS Medicinal Chemistry Letters. 2 (2): 124–129. doi:10.1021/ml1002508. PMC 4018048. PMID 24900290.
  4. Chris Miller; Maysoun Shomali; C Richard Lyttle; Gary Hattersley (24 June 2012). A Selective Androgen Receptor Modulator (RAD140) Induces Inflammation in Rat Right Heart Ventricle: Evidence for an Androgen-Specific, Species-Specific Mechanism. Roles of Androgen & Glucocorticoid Receptors in Physiology & Disease (Translational). Meeting Abstracts. The Endocrine Society. pp. SUN–525–SUN–525. doi:10.1210/endo-meetings.2012.nrsh.9.sun-525.


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