Prostaglandin H2

Prostaglandin H2
Names
Other names
PGH2, Endoperoxide H2, Prostaglandin R2
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
MeSH Prostaglandin+H2
Properties
C20H32O5
Molar mass 352.465 g/mol
Density 1.129 ± 40.0 g/mL
Boiling point 490 ± 40.0 °C
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Prostaglandin H2 is a type of prostaglandin and a precursor for many other biologically significant molecules. It is synthesized from arachidonic acid in a reaction catalyzed by a cyclooxygenase enzyme.[1]

It is acted upon by:

It rearranges non-enzymatically to:

Use of Prostaglandin H2:

  • regulating the constriction and dilation of blood vessels
  • stimulating platelet aggregation

Effects of Aspirin on Prostaglandin H2:

  • Aspirin has been hypothesized to block the conversion of arachidonic acid to Prostaglandin

References

  1. "The Cyclooxygenase Reaction Mechanism". ACS Publications. Retrieved 18 April 2016.

2. "Prostaglandin H2". SciFinder. Retrieved 22 October 2017.

3. "Acetylation of Prostaglandin H2 Synthases by Aspirin is Inhibited by Redox Cycling of the Peroxidase". "Biochem Pharmacol. Retrieved 22 October 2017.


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