PGH2, Endoperoxide H2, Prostaglandin R2
3D model (JSmol)
|Molar mass||352.465 g/mol|
|Density||1.129 ± 40.0 g/mL|
|Boiling point||490 ± 40.0 °C|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Prostaglandin H2 is a type of prostaglandin and a precursor for many other biologically significant molecules. It is synthesized from arachidonic acid in a reaction catalyzed by a cyclooxygenase enzyme.
It is acted upon by:
- Prostacyclin synthase to create prostacyclin
- Thromboxane-A synthase to create thromboxane A2 and 12-(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid (HHT) (see 12-Hydroxyheptadecatrienoic acid)
- Prostaglandin D2 synthase to create prostaglandin D2
- Prostaglandin E synthase to create prostaglandin E2
It rearranges non-enzymatically to:
- A mixture of 12-(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid (HHT) and 12-(S)-hydroxy-5Z,8Z,10E-heptadecatrienoic acid (see 12-Hydroxyheptadecatrienoic acid)
Use of Prostaglandin H2:
- regulating the constriction and dilation of blood vessels
- stimulating platelet aggregation
Effects of Aspirin on Prostaglandin H2:
- Aspirin has been hypothesized to block the conversion of arachidonic acid to Prostaglandin
- "The Cyclooxygenase Reaction Mechanism". ACS Publications. Retrieved 18 April 2016.
2. "Prostaglandin H2". SciFinder. Retrieved 22 October 2017.
3. "Acetylation of Prostaglandin H2 Synthases by Aspirin is Inhibited by Redox Cycling of the Peroxidase". "Biochem Pharmacol. Retrieved 22 October 2017.