P2RX1

P2RX1
Identifiers
AliasesP2RX1, P2X1, purinergic receptor P2X 1
External IDsMGI: 1098235 HomoloGene: 1921 GeneCards: P2RX1
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.2Start3,896,592 bp[1]
End3,916,500 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5023

18436

Ensembl

ENSG00000108405

ENSMUSG00000020787

UniProt

P51575

P51576

RefSeq (mRNA)

NM_002558

NM_008771

RefSeq (protein)

NP_002549

NP_032797

Location (UCSC)Chr 17: 3.9 – 3.92 MbChr 11: 73 – 73.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

P2X purinoceptor 1 is a protein that in humans is encoded by the P2RX1 gene.[5]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Expressed in smooth muscle and platelets. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.[6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000108405 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020787 - Ensembl, May 2017
  3. "Human PubMed Reference:".
  4. "Mouse PubMed Reference:".
  5. Valera S, Talabot F, Evans RJ, Gos A, Antonarakis SE, Morris MA, Buell GN (Nov 1996). "Characterization and chromosomal localization of a human P2X receptor from the urinary bladder". Receptors Channels. 3 (4): 283–9. PMID 8834001.
  6. "Entrez Gene: P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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