Clinical data
Trade names Ogyline, Planor, Miniplanor
Synonyms RU-2010; A-301; 17α-Ethynyltrienolone; 17α-Ethynyltrenbolone; Δ9,11-Norethisterone; 17α-Ethynylestra-4,9,11-trien-17β-ol-3-one
Routes of
By mouth
Drug class Progestin; Progestogen; Androgen; Anabolic steroid
ATC code
CAS Number
PubChem CID
ECHA InfoCard 100.011.544
Chemical and physical data
Formula C20H22O2
Molar mass 294.387 g/mol
3D model (JSmol)

Norgestrienone, sold under the brand names Ogyline, Planor, and Miniplanor, is a progestin medication which has been used in birth control pills, sometimes in combination with ethinylestradiol.[1][2][3][4][5] It was developed by Roussel Uclaf and has been registered for use only in France.[4][5][6] Under the brand name Planor, it has been marketed in France as 2 mg norgestrienone and 50 μg ethinylestradiol tablets.[7] It is taken by mouth.[5]

Norgestrienone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.[8] It has some androgenic activity.[9][10][11][12]

Norgestrienone was first described in the literature in 1965.[10] It is sometimes referred to as a "second-generation" progestin.[13] Norgestrienone is no longer available.[14]

Medical uses

Norgestrienone was used in hormonal contraception to prevent pregnancy.[2][7] It has typically been used as an oral contraceptive at a dosage of 2 mg/day in combination with ethinylestradiol and 350 µ/day when used alone.[5]

Side effects



Norgestrienone has been found to possess similar affinity for the progesterone receptor and androgen receptor,[8] and in accordance, has some androgenic activity.[9][10][11][12] The androgenic activity of norgestrienone is greater than that of other 19-nortestosterone derivatives due to the presence of the C9(11) double bond, which enhances said activity.[12] The ratio of progestogenic to androgenic activity appears to be much lower for norgestrienone that it is for other 19-nortestosterone progestins such as norethisterone and levonorgestrel.[15][16][17][18] Gestrinone, the 18-methyl analogue of norgestrienone, has even greater androgenic activity than norgestrienone, as this modification increases androgenic activity similarly.[12]

Relative affinities (%) of norgestrienone and related steroids[15][16][17][18]
Gestrinone75–7683–85<0.1, 3–10773.2??
Values are percentages (%). Reference ligands (100%) were progesterone for the PR, testosterone for the AR, E2 for the ER, DEXA for the GR, aldosterone for the MR, DHT for SHBG, and cortisol for CBG.


The metabolism of norgestrienone in humans has been studied.[19]


Norgestrienone, also known as 17α-ethynyl-19-nor-δ9,11-testosterone or as 17α-ethynylestra-4,9,11-trien-17β-ol-3-one, as well as δ9,11-norethisterone or 17α-ethynyltrienolone (17α-ethynyltrenbolone), is a synthetic estrane steroid and a derivative of testosterone and 19-nortestosterone.[1][4][20] It is structurally related to the anabolic steroid trenbolone (19-nor-δ9,11-testosterone; the non-17α-ethynylated analogue of norgestrienone), the progestogenic and androgenic steroid gestrinone (the 13β-ethyl variant or 18-methyl derivative of norgestrienone), and the anabolic steroid tetrahydrogestrinone (the 18-methyl and 17α-ethyl variant of norgestrienone).[1][4][21]


Norgestrienone was first described in the literature in 1965.[10] It is sometimes referred to as a "second-generation" progestin based on its time of introduction.[13]

Society and culture

Generic names

Norgestrienone is the generic name of the drug and its INN.[1][2][4] It is also known by its developmental code names RU-2010 and A-301.[1][2][4]

Brand names

Norgestrienone has been marketed under the brand names Ogyline, Planor, and Miniplanor.[1][2][4]


Norgestrienone is no longer marketed and hence is no longer available in any country.[14] It was previously used in France.[14][4] The medication was never marketed in the United States.[22]


Norgestrienone has been studied for use in male hormonal contraception.[23]


  1. 1 2 3 4 5 6 Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 887–. ISBN 978-1-4757-2085-3.
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  3. Diaz S, Pavez M, Quinteros E, Diaz J, Robertson DN, Croxatto HB (October 1978). "Clinical trial with subdermal implants containing norgestrienone". Contraception. 18 (4): 429–40. doi:10.1016/0010-7824(78)90027-6. PMID 720075.
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  6. McGuire JL (2000). Pharmaceuticals, 4 Volume Set. Wiley. p. 1580,1599. ISBN 978-3-527-29874-7.
  7. 1 2 IARC Working Group on the Evaluation of Carcinogenic Risks to Humans; World Health Organization; International Agency for Research on Cancer (2007). Combined Estrogen-progestogen Contraceptives and Combined Estrogen-progestogen Menopausal Therapy. World Health Organization. pp. 455–. ISBN 978-92-832-1291-1.
  8. 1 2 Loughney DA, Schwender CF (December 1992). "A comparison of progestin and androgen receptor binding using the CoMFA technique". Journal of Computer-Aided Molecular Design. 6 (6): 569–81. doi:10.1007/bf00126215. PMID 1291626.
  9. 1 2 Axelrod J (1 January 1982). Biochemical Actions of Hormones. Academic Press. ISBN 978-0-12-452809-3.
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  11. 1 2 Di Giulio RT, Monosson E (6 December 2012). Interconnections Between Human and Ecosystem Health. Springer Science & Business Media. pp. 60–. ISBN 978-94-009-1523-7.
  12. 1 2 3 4 Rozenbaum H (March 1982). "Relationships between chemical structure and biological properties of progestogens". Am. J. Obstet. Gynecol. 142 (6 Pt 2): 719–24. PMID 7065053.
  13. 1 2 Weiss G (February 1999). "Risk of venous thromboembolism with third-generation oral contraceptives: A review". Am. J. Obstet. Gynecol. 180 (2 Pt 2): 295–301. doi:10.1016/S0002-9378(99)70721-0. PMID 9988833.
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  15. 1 2 Delettré J, Mornon JP, Lepicard G, Ojasoo T, Raynaud JP (January 1980). "Steroid flexibility and receptor specificity". J. Steroid Biochem. 13 (1): 45–59. doi:10.1016/0022-4731(80)90112-0. PMID 7382482.
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  17. 1 2 Ojasoo T, Raynaud JP, Doé JC (January 1994). "Affiliations among steroid receptors as revealed by multivariate analysis of steroid binding data". J. Steroid Biochem. Mol. Biol. 48 (1): 31–46. doi:10.1016/0960-0760(94)90248-8. PMID 8136304.
  18. 1 2 Raynaud, J.P.; Ojasoo, T.; Bouton, M.M.; Philibert, D. (1979). "Drug Design": 169–214. doi:10.1016/B978-0-12-060308-4.50010-X. ISBN 9781483216102. |chapter= ignored (help)
  19. Raynaud, J. P. (1971). Metabolism of contraceptive steroids in man.
  20. Lavery JP, Sanfilippo JS (6 December 2012). Pediatric and Adolescent Obstetrics and Gynecology. Springer Science & Business Media. pp. 236–. ISBN 978-1-4612-5064-7.
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  23. Scheater, S. B. (1978). The use of progestins and androgens as a male contraceptive.

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