Clinical data
Trade names Syncro-Mate B, Crestar
Synonyms Norgestamet; SC-21009; 11β-Methyl-17α-acetoxy-19-norprogesterone; 17α-Hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate
Drug class Progestin; Progestogen; Progestogen ester
CAS Number
PubChem CID
ECHA InfoCard 100.042.359
Chemical and physical data
Formula C23H32O4
Molar mass 372.498 g/mol
3D model (JSmol)

Norgestomet, or norgestamet, sold under the brand name Syncro-Mate B and Crestar, is a progestin medication which is used in veterinary medicine to control estrus and ovulation in cattle.[1][2]



Norgestomet is used in veterinary medicine.



Norgestomet is a progestogen. In addition to the progesterone receptor, it possesses weak (micromolar) affinity for the glucocorticoid receptor.[3]


Norgestomet, also known as 11β-methyl-17α-acetoxy-19-norprogesterone or as 17α-hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate, is a synthetic norpregnane steroid and a derivative of progesterone.[1][4]


Norgestomet was developed and introduced for veterinary use in the mid-1970s.[5]

Society and culture

Generic names

Norgestomet is the generic name of the drug and its INN, USAN, and BAN.[1][4] It also known as norgestamet and is known by its developmental code name SC-21009.[1][4][6]

Brand names

Norgestomet is marketed under the brand names Syncro-Mate B and Crestar.[1][4]


  1. 1 2 3 4 5 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 887–. ISBN 978-1-4757-2085-3.
  2. Charles G. Gebelein; Richard L. Dunn (1 July 1990). Progress in Biomedical Polymers. Springer Science & Business Media. pp. 356–. ISBN 978-0-306-43523-2.
  3. Moffatt RJ, Zollers WG, Welshons WV, Kieborz KR, Garverick HA, Smith MF (1993). "Basis of norgestomet action as a progestogen in cattle". Domest. Anim. Endocrinol. 10 (1): 21–30. PMID 8467644.
  4. 1 2 3 4
  5. I. Gordon (22 October 2013). Controlled Breeding in Farm Animals. Elsevier. pp. 40–. ISBN 978-1-4832-8569-6.

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