Clinical data
Synonyms CI-728; CN-5518; CN-55945
CAS Number
PubChem CID
Chemical and physical data
Formula C27H28N2O4
Molar mass 444.53 g·mol−1
3D model (JSmol)

Nitromifene (INN; also as the citrate salt nitromifene citrate (USAN), developmental code names CI-728, CN-5518, CN-55945) is a nonsteroidal selective estrogen receptor modulator (SERM) related to triphenylethylenes like tamoxifen that was never marketed.[1] It is a mixture of (E)- and (Z)-isomers that possess similar antiestrogenic activity.[2] The drug was described in 1966.[1] Along with tamoxifen, nafoxidine, and clomifene, it was one of the earliest SERMs.[3]


  1. 1 2 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 880–. ISBN 978-1-4757-2085-3.
  2. Raymond Eller Kirk; Donald Frederick Othmer (1980). Encyclopedia of chemical technology. Wiley. p. 676. ISBN 978-0-471-02065-3.
  3. Jordan VC, Morrow M (1999). "Tamoxifen, raloxifene, and the prevention of breast cancer". Endocr. Rev. 20 (3): 253–78. doi:10.1210/edrv.20.3.0368. PMID 10368771.

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