Mebolazine

Mebolazine
Clinical data
Trade names Dostalon, Roxilon
Synonyms Dimethazine; Dymethazine; Dimethasterone azine; Di(methasterone) azine; 2α,17α-Dimethyl-5α-androstan-17β-ol-3-one azine
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C42H68N2O2
Molar mass 633.02 g·mol−1
3D model (JSmol)
 NY (what is this?)  (verify)

Mebolazine (INN; brand names Dostalon and Roxilon; also known as dimethazine, dymethazine, di(methasterone) azine, or 2α,17α-dimethyl-5α-androstan-17β-ol-3-one azine) is a synthetic, orally active androgen/anabolic steroid (AAS) and a 17α-alkylated derivative of dihydrotestosterone (DHT) which is no longer marketed.[1][2] It has a unique and unusual chemical structure, being a dimer of methasterone linked at the 3-position of the A-ring by an azine group, and reportedly acts as a prodrug of methasterone.[3]

Since 2008, mebolazine has been used illegally as an ingredient is some dietary supplements,[4] including vitamin B supplements, and in the United States the Food and Drug Administration has taken legal action against such manufacturers.[5][6]

See also

References

  1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 756–. ISBN 978-1-4757-2085-3.
  2. Geldof L, Tudela E, Lootens L, van Lysebeth J, Meuleman P, Leroux-Roels G, van Eenoo P, Deventer K (2016). "In vitro and in vivo metabolism studies of dimethazine". Biomed. Chromatogr. 30 (8): 1202–9. doi:10.1002/bmc.3668. PMID 26663462.
  3. Clemens, Roger; Pressman, Peter (2015). "Nutritional and Dietary Supplements: Code or Concern". Preventive Nutrition: 47–62. doi:10.1007/978-3-319-22431-2_3. ISBN 978-3-319-22430-5.
  4. Rahnema, C. D.; Crosnoe, L. E.; Kim, E. D. (2015). "Designer steroids - over-the-counter supplements and their androgenic component: Review of an increasing problem". Andrology. 3 (2): 150. doi:10.1111/andr.307. PMID 25684733.
  5. See, for example: "FDA Warns Consumers About Health Risks With Healthy Life Chemistry Dietary Supplement". Food and Drug Administration.
  6. "Criminal Investigations (2011) Dietary Supplements Manufacturer Sentenced". Department of Justice.


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