|Date of birth||2 August 1967|
|Place of birth||Bellinzona, Switzerland|
|2000–2001||Pescara (assistant coach)|
|2001–2002||Giulianova (assistant coach)|
|2002–2004||Treviso (assistant coach)|
|* Senior club appearances and goals counted for the domestic league only|
Born in Bellinzona, Switzerland, Giampaolo grew up in Giulianova. During his playing career, he was a midfielder who played for several Serie C teams, including Giulianova Calcio, Gubbio, Licata and Siracusa, before making his Serie B debut for Fidelis Andria in 1995. He retired in 1997, after a season played with Gualdo, following an ankle injury.
After his retirement, Giampaolo was signed as scout for Serie B side Pescara Calcio, and successively promoted as assistant coach in 2000. In 2001, he was appointed assistant coach of Serie C1 side Giulianova Calcio, in support of Adriano Buffoni. Both left on April 2002, despite the team was fully involved in a fight for a playoff placement, citing bad relationships with the club's management. In 2002–03, both Buffoni and Giampaolo signed for Treviso of Serie C1, leading the team to an immediate promotion to Serie B and saving the team from relegation the following season.
In 2004–05, Giampaolo moved to Ascoli, where he again acted as assistant coach of unknown manager Massimo Silva. This was often cited as a trick in order to allow Giampaolo to coach the team, as he was not in possess of a valid coaching licence at the time. The season ended in a good sixth place, which allowed Ascoli to play promotion playoffs, where it was defeated by Torino Calcio. However, following a serie of cancellations by the federation, Ascoli was admitted to play Serie A the next season, and both Giampaolo and Silva were confirmed to coach a team built in only two weeks, with the only goal to maintain a place in Italian top division. On February 2006, Giampaolo was disqualified for two months by the Italian Football Federation for having acted as first team head coach without a valid coaching licence. Successively, Giampaolo was admitted to join the Coverciano coaching course, and, after having saved Ascoli from relegation, he was announced as coach of Cagliari Calcio.
On September 2006, Marco Giampaolo was involved in a freak training ground accident, the 39-year-old boss was hit on the head by a wayward ball and, despite continuing with the training session, developed symptoms of concussion soon after. The coach was taken to hospital as a precautionary measure.
On December 17, 2006, after a 3–1 away defeat to Udinese in a league match, Cagliari boss Massimo Cellino announced to have sacked Giampaolo, citing coach's loss of confidence with the team. However, on February 26, 2007 Cellino decided to sack Franco Colomba and reinstate Giampaolo back at the Cagliari head coach position. After having led Cagliari to avoid relegation, he was confirmed for the 2007–08, but he was sacked again on November 13 and replaced by Nedo Sonetti, leaving the rossoblu in last place with nine points (but with one match less than other teams). He was later called once again to return at the helm of the rossoblu, following the dismissal of Sonetti, but he ultimately rejected the offer, citing his unwillingness to do so. He successively rescinded his contract with Cagliari, and on June 2008 was announced head coach of Siena for the 2008–09 season, who was fired on 29 October 2009.
On October 30, 2011 he was sacked because of bad results, leaving Cesena at bottom of Serie A table with just 3 points.
On July 2013 he was named new head coach of Serie B club Brescia. He left Brescia by mutual consent on 25 September 2013 after having stated his intention to quit the club following a heated home loss to Crotone and Giampaolo's disappearance for three days (which also led to assistant coach Fabio Micarelli and technical consultant Luigi Maifredi fulfilling his role for a single league game against Carpi) after confronting with the club supporters.
On 9 June 2015 it was announced that Giampaolo was named new coach of Empoli.
He has a brother, Federico Giampaolo, who is a former striker.
- "Cagliari sack Giampaolo – official". Football Italia. 2007-11-13. Archived from the original on 2007-11-14. Retrieved 2007-11-13.
- "Marco Giampaolo è il nuovo allenatore del Catania" (in Italian). Calcio Catania. 2010-05-30. Archived from the original on 2011-07-27. Retrieved 2010-05-30.
- "COMUNICATO STAMPA" (in Italian). Calcio Catania. 18 January 2011. Archived from the original on 27 July 2011. Retrieved 18 January 2011.
- "Giampaolo è il nuovo allenatore del Brescia Calcio" [Giampaolo is the new Brescia head coach] (in Italian). Brescia Calcio. 2 July 2013. Retrieved 6 July 2013.