March 2, 1938|
University of Chicago (B.S.) |
Harvard Medical School (M.D.)
|Awards||European Inventor of the Year (2006)|
Lubert Stryer (born March 2, 1938, in Tianjin, China) is the Mrs. George A. Winzer Professor of Cell Biology, Emeritus, at the Stanford University School of Medicine. His research over more than four decades has been centered on the interplay of light and life. In 2007 he received the National Medal of Science from President Bush at a ceremony at the White House for elucidating the biochemical basis of signal amplification in vision, pioneering the development of high density microarrays for genetic analysis, and authoring the standard undergraduate biochemistry textbook, Biochemistry. It is now in its eighth edition and also edited by Jeremy Berg, John L. Tymoczko and Gregory J. Gatto, Jr.
Stryer received his B.S. degree from the University of Chicago in 1957 and his M.D. degree from Harvard Medical School. He was a Helen Hay Whitney Research Fellow in the Department of Physics at Harvard and then at the MRC Laboratory of Molecular Biology in Cambridge, England, before joining the faculty of the Department of Biochemistry at Stanford in 1963. In 1969 he moved to Yale to become Professor of Molecular Biophysics and Biochemistry, and in 1976, he returned to Stanford to head a new Department of Structural Biology.
Stryer and coworkers pioneered the use of fluorescence spectroscopy, particularly Förster resonance energy transfer (FRET), to monitor the structure and dynamics of biological macromolecules. In 1967, Stryer and Haugland showed that the efficiency of energy transfer depends on the inverse sixth power of the distance between the donor and acceptor, as predicted by Förster's theory. They proposed that energy transfer can serve as a spectroscopic ruler to reveal proximity relationships in biological macromolecules.
A second contribution was Stryer's discovery of the primary stage of amplification in visual excitation. Stryer, together with Fung and Hurley, showed that a single photoexcited rhodopsin molecule activates many molecules of transducin, which in turn activate many molecules of a cyclic GMP phosphodiesterase. Stryer's laboratory has also contributed to our understanding of the role of calcium in visual recovery and adaptation.
Stryer participated in developing light-directed, spatially addressable parallel chemical synthesis for the synthesis of peptides and polynucleotides. Light-directed combinatorial synthesis has been used by Stephen Fodor and coworkers at Affymetrix to make DNA arrays containing millions of different sequences for genetic analyses.
- American Chemical Society Award in Biological Chemistry (Eli Lilly Award in Biological Chemistry, 1970)
- American Academy of Arts and Sciences (elected 1975)
- National Academy of Sciences (elected 1984)
- American Association for the Advancement of Science Newcomb Cleveland Prize (1992)
- Honorary Doctor of Science degree, University of Chicago, 1992
- Molecular Bioanalytics Award, German Society for Biochemistry and Molecular Biology, 2002
- American Philosophical Society (2006)
- National Medal of Science (2006)
- European Inventor of the Year 2006 in the category "Small and medium-sized enterprises"
- Richard P. Haugland (Ph.D. 1970), founder of Molecular Probes, Inc.
- Richard A. Mathies (postdoc), Dean of the College of Chemistry, University of California, Berkeley,
- Tobias Meyer (postdoc), now Professor, Department of Chemical and Systems Biology, Stanford University
- Cheng-Wen Wu (postdoc), former founding president of the Taiwan National Health Research Institutes, 1996-2005, now Professor at the Taiwan Medical College.
- Jeremy M. Berg, co-author of widely used Biochemistry textbook
- "Lubert Stryer".
- "Archived copy". Archived from the original on 2012-07-20. Retrieved 2012-03-10.
- "President to Award 2005-2006 National Medals of Science and National Medals of Technology Honoring Nation's Leading Researchers, Inventors and Innovators - NSF - National Science Foundation".
- Stryer; et al. (2015). Biochemistry (8 ed.). Palgrave Macmillan. ISBN 1464126100. Retrieved 16 October 2015.
- "Archived copy". Archived from the original on 2012-11-14. Retrieved 2012-04-01.
- "Alumni - MRC Laboratory of Molecular Biology". MRC Laboratory of Molecular Biology.
- McCarthy, Pumtiwitt. "Everything is illuminated: 'Reflections' on light and life by Lubert Stryer". American Society for Biochemistry and Molecular Biology. Retrieved 19 June 2016.
- Stryer, L (1968). "Fluorescence spectroscopy of proteins". Science. 1632: 526–533.
- "Archived copy". Archived from the original on 2011-06-14. Retrieved 2010-10-18.
- Stryer, L.; Haugland, R.P. (1967). "Energy transfer: a spectroscopic ruler". Proc. Natl. Acad. Sci. USA. 58: 719–725. doi:10.1073/pnas.58.2.719. PMC 335693
. PMID 5233469.
- Lakowicz, J.R., 2006. Principles of Fluorescence Spectroscopy (Springer, 3rd ed., p. 449)
- Fung, B.; Hurley, J.B.; Stryer, L. (1981). "Flow of information in the light-triggered cyclic nucleotide cascade of vision". Proc. Natl. Acad. Sci. USA. 78: 152–156. doi:10.1073/pnas.78.1.152. PMC 319009
. PMID 6264430.
- "Chemical & Engineering News - Serving the chemical, life sciences and laboratory worlds".
- Koch, K.-W.; Stryer, L. (1988). "Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ion". Nature. 334: 64–66. doi:10.1038/334064a0. PMID 2455233.
- <Ames, J.B., Ishima, R., Tanaka, T., Gordon, J.I., Stryer, L., Ikura, M., 1997. Molecular mechanics of calcium-myristoyl switches. Nature 389:198-202
- Burgoyne, R.D.; Weiss, J.L. (2001). "The neuronal calcium sensor family of Ca2+-binding proteins". Biochem. J. 353: 1–12. doi:10.1042/bj3530001. PMC 1221537
- Fodor, S.P.A.; Read, J.L.; Pirrung, M.C.; Stryer, L.; Lu, A.T.; Solas, D. (1991). "Light-directed, spatially addressable parallel chemical synthesis". Science. 251: 767–773. doi:10.1126/science.1990438. PMID 1990438.
- Fodor, S.P.A., Pirrung, M.C., Read, J.L., and Stryer, L., Array of oligonucleotides on a solid substrate. U.S. Patent No. 5,445,934. Issued August 29, 1995
- "2007 Newcomb Cleveland Prize Recipients". AAAS - The World's Largest General Scientific Society.
- Latchman,D.S. (1995) Trends Biochem. Sci. 20:488.
- "BIO2010: Transforming Undergraduate Education for Future Research Biologists - The National Academies Press".
- Kennedy, D (2003). "Points of View: Is Bio2010 the Right Blueprint for the Biology of the Future?". Cell Biol Educ. 2: 224–7. doi:10.1187/cbe.03-10-0039. PMC 256982
. PMID 14673487.
- "Recipients - ACS Division of Biological Chemistry Website".
- "American Academy of Arts & Sciences".
- "National Academy of Sciences".
- 1992 http://convocation.uchicago.edu/page/1990
- European Patent Office. "EPO - Stephen P.A. Fodor, Michael C. Pirrung, J. Leighton Read and Lubert Stryer (Affymax Research Institute, Palo Alto, USA)".
- "Faculty & Research".
- "Archived copy". Archived from the original on 2009-04-11. Retrieved 2012-04-01.