List of opioids

This is a list of opioids, opioid antagonists and inverse agonists.

Opium and poppy straw derivatives

Crude opiate extracts whole opium products

Natural opiates

Opium alkaloids

Alkaloid salts mixtures

Semisynthetics including Bentley compounds

Morphine family

Structures of Morphine family
Morphine family
14-Hydroxymorphine 2,4-Dinitrophenylmorphine 6-Methyldihydromorphine 6-Methylenedihydrodesoxymorphine 6-Acetyldihydromorphine hydrochloride
Azidomorphine Chlornaltrexamine Chloroxymorphamine Desomorphine
(Dihydrodesoxymorphine)
Dihydromorphine
Ethyldihydromorphine Hydromorphinol Methyldesorphine N-Phenethylnormorphine 6-nicotinoyldihydromorphine
RAM-378

3,6-diesters of morphine

Structures
3,6-diesters of morphine
Acetylpropionylmorphine 3,6-Dibutanoylmorphine Diacetyldihydromorphine
(dihydroheroin, acetylmorphinol)
Dibutyrylmorphine Dibenzoylmorphine Diformylmorphine
Dipropanoylmorphine Heroin
(diacetylmorphine)
Nicomorphine

Codeine-dionine family

Structures

Morphinones and morphols

Morphides

  • α-Chlorocodide (= Chlorocodide) 
  • β-Chlorocodide 
  • α-Chloromorphide (= Chloromorphide)
  • Bromocodide 
  • Bromomorphide 
  • Chlorodihydrocodide 
  • Chloromorphide
  • Codide 
Structures
Morphides
α-chlorocodide β-chlorocodide Bromomorphide
Chlorodihydrocodide. Chloromorphide Codide

Dihydrocodeine series

Nitrogen morphine derivatives

Structures
Morphides
1-Nitrocodeine Codeine-N-oxide Morphine-N-oxide

Hydrazones

Structures
Hydrazones
Oxymorphazone

Halogenated morphine derivatives

Structures
Other open chain opioids

1-Bromocodeine

1-Chlorocodeine

1-Iodomorphine

Active opiate metabolites

Morphinans

Morphinan series

Structures
Other Morphinans
4-chlorophenylpyridomorphinan Cyclorphan Dextrallorphan Levargorphan Levophenacylmorphan
Levomethorphan Norlevorphanol N-Methylmorphinan Oxilorphan Phenomorphan
Dextromethorphan Levomethorphan Morphanol Ro4-1539 Stephodeline Xorphanol

Others

Structures
Other Morphinans
1-Nitroaknadinine 14-episinomenine 5,6-Dihydronorsalutaridine 6-Keto Nalbuphine Aknadinine
Butorphanol Cephakicine Cephasamine Cyprodime Drotebanol
Fenfangjine G Nalbuphine Sinococuline Sinomenine Tannagine

Benzomorphans

4-Phenylpiperidines

Pethidines (meperidines)

Prodines

Ketobemidones

Others

Structures
Other phenylpiperidines
Alvimopan Loperamide Picenadol

Open chain opioids

Amidones

Methadols

Structures
Other open chain opioids

Alphaacetylmethadol

Dimepheptanol

Levacetylmethadol

Noracetylmethadol

Moramides

Thiambutenes

Phenalkoxams

Ampromides

Structures

Others

Structures
Other open chain opioids

Embutramide

IC-26

Isoaminile

Lefetamine

R-4066

Anilidopiperidines

Oripavine derivatives

Phenazepanes

Pirinitramides

Structures
Pirinitramides

Bezitramide

Piritramide

Benzimidazoles

Structures
Benzimidazoles

Clonitazene

Etonitazene

Nitazene: R = Hydrogen

Indoles

Beta-Amino Ketones

Diphenylmethylpiperazines

Structures
Diphenylmethylpiperazines

BW373U86

DPI-221

DPI-287

DPI-3290

SNC-80

Opioid peptides

Dynorphins

Structures

Endomorphins

Endorphins

Enkephalins

Propeptides

Others / unknown

Others

Opioid antagonists and inverse agonists

Biased ligands

Receptor heteromer targeting ligands

Uncategorized opioids

Combination drug formulations containing opioids

See also

References

  1. ChemIndex CAS Registry Number 3371-56-0
  2. ChemIndex CAS Registry Number 509-56-8
  3. ChemIndex CAS Registry Number 63715-94-6
  4. NCBI PubChem SID 750205
  5. chembase cbid_346222
  6. Gomes I, Fujita W, Gupta A, Saldanha SA, Saldanha AS, Negri A, Pinello CE, Eberhart C, Roberts E, Filizola M, Hodder P, Devi LA (2013). "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proc. Natl. Acad. Sci. U.S.A. 110 (29): 12072–7. Bibcode:2013PNAS..11012072G. doi:10.1073/pnas.1222044110. PMC 3718106. PMID 23818586.
  7. Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS (2011). "N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers". Proc. Natl. Acad. Sci. U.S.A. 108 (12): 5098–103. Bibcode:2011PNAS..108.5098Y. doi:10.1073/pnas.1016277108. PMC 3064379. PMID 21385944.
  • Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time." Russian Chemical Bulletin. August 2008, Volume 57, Issue 8, pp 1773–1774. Date: 11 Aug 2009; I. V. Evsikova, S. K. Moiseev, P. V. Petrovskii, V. N. Kalinin. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1739–1740
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