Clinical data
Synonyms LEO-1727; 19-Nortestosterone 17β-N-(2-chloroethyl)-N-nitrosocarbamate; Nandrolone chloroethylnitrosocarbamate
Routes of
Intramuscular injection
Drug class Nitrogen mustard; Alkylating antineoplastic agent; Androgen; Anabolic steroid; Androgen ester; Progestogen
CAS Number
PubChem CID
Chemical and physical data
Formula C21H29ClN2O4
Molar mass 408.919 g/mol
3D model (JSmol)

LS-1727, also known as nandrolone 17β-N-(2-chloroethyl)-N-nitrosocarbamate, is a synthetic, injected anabolic–androgenic steroid (AAS) and a nitrosocarbamate[1] ester of nandrolone (19-nortestosterone) that was developed as an alkylating antineoplastic agent but was never marketed.[2][3][4]

See also


  1. Reynolds RC, Tiwari A, Harwell JE, Gordon DG, Garrett BD, Gilbert KS, Schmid SM, Waud WR, Struck RF (2000). "Synthesis and evaluation of several new (2-chloroethyl)nitrosocarbamates as potential anticancer agents". J. Med. Chem. 43 (8): 1484–8. doi:10.1021/jm990417j. PMID 10780904.
  2. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 660–. ISBN 978-1-4757-2085-3.
  3. Müntzing J, Kirdani RY, Williams PD, Murphy GP (1981). "Effect of LS 1727, a nitrosocarbamate of 19-nortestosterone, on the R-3327 rat prostatic adenocarcinoma". Res. Commun. Chem. Pathol. Pharmacol. 32 (2): 309–16. PMID 7244365.
  4. Hartley-Asp B, Wilkinson R, Venitt S, Harrap KR (1981). "Studies on the mechanism of action of LS 1727, a nitrosocarbamate of 19-nortestosterone". Acta Pharmacol Toxicol (Copenh). 48 (2): 129–38. PMID 6167141.

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