GLRB

GLRB
Identifiers
AliasesGLRB, HKPX2, glycine receptor beta
External IDsMGI: 95751 HomoloGene: 20224 GeneCards: GLRB
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q32.1Start157,076,057 bp[1]
End157,172,090 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2743

14658

Ensembl

ENSG00000109738

ENSMUSG00000028020

UniProt

P48167

P48168

RefSeq (mRNA)

NM_000824
NM_001166060
NM_001166061

RefSeq (protein)

NP_000815
NP_001159532
NP_001159533

Location (UCSC)Chr 4: 157.08 – 157.17 MbChr 3: 80.84 – 80.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.[5][6][7]

The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM][7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000109738 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028020 - Ensembl, May 2017
  3. "Human PubMed Reference:".
  4. "Mouse PubMed Reference:".
  5. Milani N, Mulhardt C, Weber RG, Lichter P, Kioschis P, Poustka A, Becker CM (Oct 1998). "The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism". Genomics. 50 (3): 341–5. doi:10.1006/geno.1998.5324. PMID 9676428.
  6. Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR (Oct 1996). "The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes". Brain Res Mol Brain Res. 35 (1–2): 211–9. doi:10.1016/0169-328x(95)00218-h. PMID 8717357.
  7. 1 2 "Entrez Gene: GLRB glycine receptor, beta".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.