GABRE

GABRE
Identifiers
AliasesGABRE, gamma-aminobutyric acid type A receptor epsilon subunit
External IDsHomoloGene: 68425 GeneCards: GABRE
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq28Start151,953,124 bp[1]
End151,974,680 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2564

n/a

Ensembl

ENSG00000102287

n/a

UniProt

P78334

n/a

RefSeq (mRNA)

NM_004961
NM_021984
NM_021987
NM_021990

n/a

RefSeq (protein)

NP_004952

n/a

Location (UCSC)Chr X: 151.95 – 151.97 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Gamma-aminobutyric acid receptor subunit epsilon is a protein that in humans is encoded by the GABRE gene.[3][4][5]

The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]

Brainstem expression of ε subunit-containing GABAA receptors is upregulated during pregnancy, particularly in the ventral respiratory group.[6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000102287 - Ensembl, May 2017
  2. "Human PubMed Reference:".
  3. Davies PA, Hanna MC, Hales TG, Kirkness EF (Mar 1997). "Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit". Nature. 385 (6619): 820–3. doi:10.1038/385820a0. PMID 9039914.
  4. Garret M, Bascles L, Boue-Grabot E, Sartor P, Charron G, Bloch B, Margolskee RF (Apr 1997). "An mRNA encoding a putative GABA-gated chloride channel is expressed in the human cardiac conduction system". J Neurochem. 68 (4): 1382–9. doi:10.1046/j.1471-4159.1997.68041382.x. PMID 9084408.
  5. 1 2 "Entrez Gene: GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon".
  6. Hengen KB et al. (2012). PMID 22303446

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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