Clinical data
ATC code
  • none
CAS Number
PubChem CID
ECHA InfoCard 100.164.846
Chemical and physical data
Formula C19H17N3O
Molar mass 303.36 g/mol
3D model (JSmol)
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Evodiamine is a chemical extracted from the plant genus Tetradium, which has been shown to reduce fat uptake in mouse studies. It is suspected that its mechanism of action is similar to that of capsaicin.[1] As such, it has been included in some dietary supplements. Neither its fat-burning effects in humans nor any potential side effects have been empirically established.

Evodiamine acts primarily as a thermogenic and stimulant.[2]

Evodiamine may also act in a manner comparable to tianeptine by increasing the number of serotonin transporters available in the brain, enhancing the reuptake of serotonin.[3]


  1. Kobayashi, Y.; Nakano, Y.; Kizaki, M.; Hoshikuma, K.; Yokoo, Y.; Kamiya, T. (2001). "Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist". Planta Medica. 67 (7): 628–633. doi:10.1055/s-2001-17353. PMID 11582540.
  2. Wang, T.; Wang, Y.; Kontani, Y.; Kobayashi, Y.; Sato, Y.; Mori, N.; Yamashita, H. (2008). "Evodiamine improves diet-induced obesity in an uncoupling protein-1-independent manner: involvement of antiadipogenic mechanism and extracellularly regulated kinase / mitogen-activated protein kinase signaling". Endocrinology. 149 (1): 358–366. doi:10.1210/en.2007-0467. PMID 17884939.
  3. Hu, Y.; Ehli, E. A.; Hudziak, J. J.; Davies, G. E. (2011). "Berberine and evodiamine influence serotonin transporter (5-HTT) expression via the 5-HTT-linked polymorphic region". The Pharmacogenomics Journal. 12 (5): 372–378. doi:10.1038/tpj.2011.24. PMID 21647174.
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