Clinical data
Synonyms Leo 271 f; Estrone 17β-3-N-bis(2-chloroethyl)carbamate; Estrone–cytostatic complex
Pharmacokinetic data
Elimination half-life 14 hours[1]
CAS Number
PubChem CID
Chemical and physical data
Formula C23H29Cl2NO3
Molar mass 438.387 g/mol
3D model (JSmol)

Estromustine (developmental code name Leo 271 f), also known as estrone 17β-3-N-bis(2-chloroethyl)carbamate or estrone–cytostatic complex,[2] is a major active metabolite of the cystotatic estrogen and nitrogen mustard alkylating antineoplastic agent estramustine phosphate, a medication used in the treatment of prostate cancer.[1][3]

See also


  1. 1 2 Bruce A. Chabner; Dan L. Longo (7 December 2011). Cancer Chemotherapy and Biotherapy: Principles and Practice. Lippincott Williams & Wilkins. pp. 252–. ISBN 978-1-4511-4820-6.
  3. Medical Subject Headings: Supplementary chemical records. The Library. 1993. p. 684.

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