Environmental impact of pharmaceuticals and personal care products
The environmental effect of pharmaceuticals and personal care products (PPCPs) is is currently being widely investigated. PPCPs include substances used by individuals for personal health or cosmetic reasons and the products used by agribusiness to boost growth or health of livestock. More than twenty million tons of PPCPs are produced every year. PPCPs have been detected in water bodies throughout the world. The effects of these chemicals on humans and the environment are not yet known, but to date there is no scientific evidence that they affect human health.
Further research is needed to evaluate the risks of toxicity, persistence, and bioaccumulation. The term PPCPs encompasses environmental persistent pharmaceutical pollutants (EPPPs), and PPCPs are classified as pseudo persistent organic pollutants. They are not removed from wastewater by conventional methods. The European Union describes pharmaceutical residues with the potential of contamination of water and soil as "priority substances".
Since the 1990s water contamination by pharmaceuticals has been an environmental issue of concern. In addition, it is important to note that most Public health professionals in the United States began writing reports of Pharmaceutical contamination in water ways Since the 1970s.” Most pharmaceuticals are deposited in the environment through human consumption and excretion, and are often filtered ineffectively by wastewater treatment plants which are not designed to manage them. Once in the water they can have diverse, subtle effects on organisms, although research is limited. Pharmaceuticals may also be deposited in the environment through improper disposal, runoff from sludge fertilizer and reclaimed wastewater irrigation, and leaky sewage. In 2009 an investigative report by Associated Press concluded that U.S. manufacturers had legally released 271 million pounds of compounds used as drugs into the environment, 92 percent of which was the industrial chemicals phenol and hydrogen peroxide, which are also used an antiseptics. It could not distinguish between drugs released by manufacturers as opposed to the pharmaceutical industry. It also found that an estimated 250 million pounds of pharmaceuticals and contaminated packaging were discarded by hospitals and long-term care facilities. The series of articles lead to a hearing called by the United State Senate subcommittee on Infrastructure security, Water Quality, and transportation safety.” This hearing was designed to address the levels of pharmaceutical contaminants in U.S. drinking water. This was the first time that pharmaceutical giants were questioned about their waste disposal methods. “No federal regulations or laws were created as a result of the hearing.” “Between the years of 1970-2018 more than 3000 pharmaceutical prescriptions were created but only 17 prescriptions are screened or tested for in waterways”. Alternately, “There are no studies designed to examine the effects of pharmaceutical contaminated drinking water on human health.” In parallel, the European Union is the second biggest consumer in the world (24% of the world total) after the USA and in the majority of EU Member States, around 50% of unused human medicinal products is not collected to be discharged properly. In the EU between 30 and 90% of the orally administered dose is estimated to be excreted as active substance in the urine.
The term environmental persistent pharmaceutical pollutants (EPPP) was suggested in the 2010 nomination of pharmaceuticals and environment as an emerging issue to Strategic Approach to International Chemicals Management (SAICM) by the International Society of Doctors for the Environment (ISDE).
Depending on the source and ingredients, there are various ways in which the public can dispose of pharmaceutical and personal care products. In the case of pharmaceutical products, the most environmentally safe disposal method is to take advantage of a community drug take-back programs that collect drugs at a central location for proper disposal. Several local public health departments in the United States have initiated pharmaceutical take-back programs. In addition, the United States Drug Enforcement Administration (DEA) periodically promotes local take-back programs as well as a program called the National Take Back Initiative.
Currently, take back programs are funded by state or local health departments or are volunteer programs through pharmacies or health care providers. In recent years, the proposition that pharmaceutical companies should be responsible for their products “from the cradle to the grave,” has been gaining traction. This philosophy suggests that the manufacturers should fund the proper disposal of pharmaceutical products. Take back programs should exist in every community, and if further information is required on the matter the city officials should be contacted. The Environmental Protection Agency and the Office of National Drug Control Policy further emphasize that if no program is available to follow the subsequent measurements:
- take the prescription drugs out of their original containers
- mix drugs with cat litter or used coffee grounds
- place the mixture into a disposable container with a lid, such as a sealable bag
- cover up any personal identification with a black marker that is on the original pill containers
- place these containers in the bag with the mixture, seal them, and place them in the trash.
After these products are properly disposed, the process of treating them for minimizing environmental effect begins. Water treatment facilities use different processes in order to minimize or fully eliminate the amount of these pollutants. This is done by using sorption where suspended solids are removed by sedimentation. Another method used is biodegradation, and through this method microorganisms, such as bacteria, feed or break down these pollutants thus eliminating them from the contaminated media.
Pharmaceuticals, or prescription and over-the-counter medications made for human use or veterinary or agribusiness purposes, are common PPCPs found in the environment. There are nine classes of pharmaceuticals included in PPCPs: hormones, antibiotics, lipid regulators, nonsteroidal anti-inflammatory drugs, beta-blockers, antidepressants, anticonvulsants, antineoplastics, and diagnostic contrast media.
Personal care products have four classes: fragrances, preservatives, disinfectants, and sunscreen agents. These products may be found in cosmetics, perfumes, menstrual care products, lotions, shampoos, soaps, toothpastes, and sunscreen. These products typically enter the environment when passed through or washed off the body and into the ground or sewer lines, or when disposed of in the trash, septic tank, or sewage system.
Traces of illicit drugs can be found in waterways and may even be carried by money.
Routes into the environment
More attention has been devoted of late to PPCPs in the environment. Two causes may contribute to this: PPCPs are actually increasing in the environment due to widespread use and/or analytical technology is better able to detect PPCPs in the environment. These substances enter the environment directly or indirectly. Direct methods include contamination of surface water by hospitals, households, industries, or wastewater treatment plants. Direct contamination can also affect the sediment and soil.
It is generally assumed (albeit hardly verified) that the production of pharmaceuticals in industrialised countries is well controlled and unharmful to the environment, due to the local legal restrictions usually required to permit production. However, a substantial fraction of the global production of pharmaceuticals takes place in low-cost production countries like India and China. Recent reports from India demonstrate that such production sites may emit very large quantities of e.g. antibiotics, yielding levels of the drugs in local surface waters higher than those found in the blood of patients under treatment.
The major route for pharmaceutical residues to reach the aquatic environment is most probably by excretion from patients undergoing pharma treatment. Since many pharmaceutical substances are not metabolized in the body they may be excreted in biologically active form, usually via the urine. Furthermore, many pharmaceutical substances are not fully taken up from the intestine (following oral administration in patients) into their blood stream. The fraction not taken up into the blood stream will remain in the gut and eventually be excreted via the faeces. Hence, both urine and faeces from treated patients contain pharmaceutical residues. Between 30 and 90% of the orally administered dose is generally excreted as active substance in the urine.
An additional source to environmental pollution with pharmaceuticals is improper disposal of unused or expired drug residues. In European countries take-back systems for such residues are usually in place (although not always utilized to full extent) while in e.g. the US only voluntary initiatives on a local basis exist. Though most of the waste goes to incineration and people are asked to throw unused or expired pharmaceuticals into the household waste investigations in Germany showed that up to 24% of liquid pharmaceuticals and 7% of tablets or ointments are disposed always or at least “rarely” via the toilet or sink.
Proper destruction of pharma residues should yield rest products without any pharmaceutical or ecotoxic activity. Furthermore, the residues should not act as components in the environmental formation of new such products. Incineration at a high temperature (>1000 degrees Celsius) is considered to fulfill the requirements, but even following such incineration residual ashes from the incineration should be properly taken care of.
Pharmaceuticals used in veterinary medicine, or as additives to animal food, pose a different problem, since they are excreted into soil or possibly open surface waters. It is well known that such excretions may affect terrestrial organisms directly, leading to extinction of exposed species (e.g. dung-beetles). Lipid-soluble pharma residues from veterinary use may bind strongly to soil particles, with little tendency to leak out to ground water or to local surface waters. More water-soluble residues may be washed out with rain or melting snow and reach both ground water and surface water streams.
Presence in the environment
The use of pharmaceuticals and personal care products (PPCPs) is on the rise with an estimated increase from 2 billion to 3.9 billion annual prescriptions between 1999 and 2009 in the United States alone. PPCPs enter into the environment through individual human activity and as residues from manufacturing, agribusiness, veterinary use, and hospital and community use. In Europe, the input of pharmaceutical residues via domestic waste water is estimated to be around 80% whereas 20% is coming from hospitals. Individuals may add PPCPs to the environment through waste excretion and bathing as well as by directly disposing of unused medications to septic tanks, sewers, or trash. Because PPCPs tend to dissolve relatively easily and do not evaporate at normal temperatures, they often end up in soil and water bodies.
Some PPCPs are broken down or processed easily by a human or animal body and/or degrade quickly in the environment . However, others do not break down or degrade easily. The likelihood or ease with which an individual substance will break down depends on its chemical makeup and the metabolic pathway of the compound.
A 2002 study by the U.S. Geological Survey found detectable quantities of one or more chemicals in 80 percent of a sampling of 139 susceptible streams in 30 states. The most common pharmaceuticals detected were nonprescription drugs; detergents, fire retardants, pesticides, natural and synthetic hormones, and an assortment of antibiotics and prescription medications were also found.
A 2006 study found detectable concentrations of 28 pharmaceutical compounds in sewage treatment plant effluents, surface water, and sediment. The therapeutic classes included antibiotics, analgesics and anti-inflammatories, lipid regulators, beta-blockers, anti-convulsant, and steroid hormones. Although most chemical concentrations were detected at low levels (nano-grams/Liter (ng/L)), there are uncertainties that remain regarding the levels at which toxicity occurs and the risks of bioaccumulation of these pharmaceutical compounds.
A study published in late 2014 reported a spike in the levels of ecstasy, ketamine, caffeine and acetaminophen in nearby rivers coinciding with a Taiwanese youth event attended by around 600,000 people. In 2018, shellfish in Puget Sound, waters that receive treated sewage from the Seattle area, tested positive for oxycodone.
Besides the identified input from human medicine there appears diffuse pollution for example from pharmaceuticals used in agriculture, too. Investigations in Germany, France and Scotland showed traces of PPCPs upstream of waste water treatment plant effluents to rivers, too.
The scope of human exposure to pharmaceuticals and personal care products from the environment is a complex function of many factors. These factors include the concentrations, types, and distribution of pharmaceuticals in the environment; the pharmacokinetics of each drug; the structural transformation of the chemical compounds either through metabolism or natural degradation processes; and the potential bioaccumulation of the drugs. More research is needed to determine the effects on humans of long-term exposure to low levels of PPCPs. The full effects of mixtures of low concentrations of different PPCPs is also unknown.
“The U.S.EPA risk assessment states that the acceptable daily intake (ADI) of pharmaceuticals is around 0.0027 mg/kg‐day “. Due to the lack of research of toxicity guidelines and their effects on human health it is difficult to determine a healthy dosage for water contaminated by pharmaceuticals. “The pharmaceutical sample size tested does not give a full representation of human exposure”. Only 17 out of 3000 prescriptions are screened for in drinking water”.
In addition, “The EPA and FDA regulations state that a drug or chemical is not considered harmful until clear evidence shows that a substance causes harm". This means that we are not testing or screening for thousands of contaminants in our drinking water. Health risk assessments have not been conducted to provide concrete evidence to link pharmaceutical contamination and adverse human health effects.
“However adverse health outcomes are displayed in aquatic organisms. Fish living near water treatment plants have been reported to be feminized. Some male fish started to develop ovaries and other feminized characteristic due to pharmaceutical pollution some species have decreased in population due to exposure of EE2 and other hormonal ECD substances.”
Although research has shown that PPCPs are present in water bodies throughout the world, no studies have shown a direct effect on human health. However, the absence of empirical data cannot rule out the possibility of adverse outcomes due to interactions or long-term exposures to these substances. Because the amounts of these chemicals in the water supply may be in the parts per trillion or parts per billion, it is difficult to chemically determine the exact amounts present. Many studies have therefore been focused to determining if the concentrations of these pharmaceuticals exist at or above the accepted daily intake (ADI) at which the designed biological outcomes can occur.
In addition to the growing concerns about human health risks from pharmaceutical drugs via environmental exposures, many researchers have speculated about the potential for inducing an antibiotic resistance. One study found 10 different antibiotics in sewage treatment effluents, surface water, and sediments. Some microbiologists believe that if antibiotic concentrations are higher than the minimum inhibitory concentrations (MICs) of a species of pathogenic bacteria, a selective pressure would be exerted and, as a result, antibiotic resistance would be selectively promoted. It has also been proven that at even sub-inhibitory concentrations (e.g., one-fourth of the MIC), several antibiotics are able to have an effect on gene expression (e.g., as shown for the modulation of expression of toxin-encoding genes in Staphylococcus aureus).
For reference the MIC of erythromycin that is effective against 90 percent of lab grown Campylobacter bacteria, the most common food-borne pathogen in the United States, is 60 ng/mL. One study found that the average concentration of erythromycin, a commonly prescribed antibiotic, was 0.09 ng/mL in water treatment plant effluents,. Additionally, transfer of genetic elements among bacteria has been observed under natural conditions in wastewater treatment plants, and selection of resistant bacteria has been documented in sewers receiving wastewaters from pharmaceutical plants. Moreover, antibiotic resistant bacteria may also remain in sewage sludge and enter the food chain if the sludge is not incinerated but used as fertilizer on agricultural land.
The relationship between risk perception and behavior is multifaceted. Risk management is most effective once the motivation behind the behavior of disposing unused pharmaceuticals is understood. There was little correlation found between the perception of risk and knowledge regarding pharmaceutical waste according to a study conducted by Cook and Bellis in 2001. This study cautioned against the effectiveness of attempting to change the public’s behavior on these health issues by warning them of the risks associated with their actions.
It is advised to take careful measures to inform the public in a way that does not impart guilt but rather public awareness. For example, a study carried out by Norlund and Garvill in Sweden (2003) that found that some people may make a personal sacrifice in terms of comfort because they feel that it would be helpful to reduce further environmental damage caused by the use of cars. Awareness of air pollution problems was a factor in their decision to take action on a more environmentally favorable choice of transportation. Thus, the goal of Bound’s project encapsulates whether the perception of risk associated with pharmaceuticals has an effect on the way in which medication is commonly disposed.
In order to conduct this study, the pharmaceuticals were grouped by their therapeutic action in order to help participants identify them. The eight therapeutic groups are listed below: antibacterials, antidepressants, antihistamines, antiepileptics, hormone treatments, and lipid regulators. Next, a survey was created to examine the disposal patterns of the participants and their perception of the existing risk or threat against the environment. Respondents were asked the following questions in part one of the survey: 1. When and how they disposed of pharmaceuticals. 2. How they perceive the risk to the environment posed by pharmaceuticals. 3. To differentiate between the risks associated with different classed of pharmaceuticals. Part two of the survey involved each of the eight pharmaceutical groups described above individually. Finally, the third part asked information about the age, sex, profession, postcode, and education of participants. The sample size of participants was precise in comparison to the actual distribution of males and females in the UK: Sample- 54.8 percent were female and 45.2 percent male vs. Actual- the UK of 51.3 percent female to 48.7 percent male. Results showed that when a medication must be discarded, 63.2 percent of participants throw them in a bin, 21.8 percent return them to a pharmacist, and 11.5 percent dispose of them via the toilet/sink, while the remaining 3.5 percent keep them. Only half of the respondents felt like pharmaceuticals could potentially be harmful to the environment. Upon examination of factors relevant to risk perception, there was no definite link found between perception and education or income.
Dr. Bound noted that participation in altruistic activities such as Environmental Conservation groups may provide members with the ability to better grasp the effects of their actions in the environment. In regards to the aquatic environment, it is hard for one to perceive the favorable effects of properly disposing medication. There also exists the plausibility that a person’s behavior will only be affected if there is a severe risk to themselves or humans as opposed to an environmental threat. Even though there are serious threats of pharmaceutical pollution resulting in the feminization of certain fish, they have a lower priority because they are not easily understood or experienced by the general public. In Jonathan P. Bound’s opinion, the provision of information about exactly how to go about disposing unused medication properly in conjunction with risk education may have a more positive and forceful effect.
Several recommendations and initiatives have been made to prevent pharmaceutical pollution in the environment. Important practices include educating patients on the importance of proper unused drug disposal, educating physicians and patients of proper drug disposal, encouraging pharmaceutical industries to implement strategies for proper disposal of drugs or recycling strategies, and enforcing hospitals to implement better management practices for disposing pharmaceutical waste.
First, it is imperative that patients become educated on pharmaceutical pollution and its hazardous effects on humans, animals, and the overall environment. By educating patients on proper disposal of unused drugs, steps are being taken to further prevent pharmaceutical waste in the environment. Consumers should take precautions before tossing out drugs in the trash or flushing them down the toilet. Community take back programs have been set up for consumers to bring back unused drugs for proper disposal. Another initiative is for pharmacies to serve as a take back site for proper drug disposal such as implementing recycling bins for customers to bring back unused or expired medicines while they’re shopping. In addition, educating physicians and patients on the importance of proper drug disposal and the environmental concern will help further reduce pharmaceutical waste.
Also, implementing initiatives for hospitals to focus on better practices for hazardous waste disposal may prove to be beneficial. The US EPA incentives hospitals to develop efficient pharmaceutical disposal practices by giving them grants. This incentive may be very beneficial to other hospitals worldwide.
Additionally, “It is critical for us to develop an analytical method of identifying, testing, and regulating the amount of pharmaceuticals in the water systems”. Data must be collected in order to accurately measure the prevalence of pharmaceuticals in drinking water. “Multiple Health risk assessments should be conducted to understand the effects of prolonged exposure to pharmaceuticals in drinking water”.
Community based programs should be developed to monitor exposure and health outcomes. We should encourage the pharmaceutical industry to develop technology that extracts pharmaceutical contains form waterways. “Extensive research must be conducted to determine the amount of pharmaceutical contamination in the environment and its effects on animals and marine life”.
While the full effects of most PPCPs on the environment are not understood, there is concern about the potential they have for harm because they may act unpredictably when mixed with other chemicals from the environment or concentrate in the food chain. Additionally, some PPCPS are active at very low concentrations, and are often released continuously in large or widespread quantities.
Because of the high solubility of most PPCPs, aquatic organisms are especially vulnerable to their effects. Researchers have found that a class of antidepressants may be found in frogs and can significantly slow their development. The increased presence of estrogen and other synthetic hormones in waste water due to birth control and hormonal therapies has been linked to increased feminization of exposed fish and other aquatic organisms. The chemicals within these PPCP products could either affect the feminization or masculinization of different fishes, therefore affecting their reproductive rates.
In addition to being found only in waterways, the ingredients of some PPCPs can also be found in the soil. Since some of these substances take a long time or cannot be degraded biologically, they make their way up the food chain. Information pertaining to the transport and fate of these hormones and their metabolites in dairy waste disposal is still being investigated, yet research suggest that the land application of solid wastes is likely linked with more hormone contamination problems. Not only does the pollution from PPCPs affect marine ecosystems, but also those habitats that depend on this polluted water.
There are various concerns about the effects of pharmaceuticals found in surface waters and specifically the threats against rainbow trout exposed to treated sewage effluents. Analysis of these pharmaceuticals in the blood plasma of fish compared to human therapeutic plasma levels have yielded vital information providing a means of assessing risk associated with medication waste in water. In a study by Dr. Jerker Fick from Umeå University rainbow trout were exposed to undiluted, treated sewage water at three different sits in Sweden. They were exposed for a total of 14 days while 25 pharmaceuticals were measured in the blood plasma at different levels for analysis. The progestin Levonorgestrel was detected in fish blood plasma at concentrations between 8.5 and 12 ng mL-1 which exceed the human therapeutic plasma level. Studies show that the measured effluent level of Levonorgestrel in the three areas was shown to reduce the fertility of the rainbow trout.
The three sites chosen for field exposures were in located in Stockholm, Gothenburg, and Umeå. They were chosen according to their varying degrees of treatment technologies, geographic locations, and size. The effluent treatment includes active sludge treatment, nitrogen and phosphorus removal (except in Umeå), primary clarification, and secondary clarification. Juvenile rainbow trout were procured from Antens fiskodling AB, Sweden and Umlax AB, Sweden. The fish were exposed to aerated, undiluted, treated effluent. Since all of the sites underwent sludge treatment, it can be inferred that they are not representative of the low end of treatment efficacy. Of the 21 pharmaceuticals that were detected in the water samples, 18 were identified in the effluent, 17 in the plasma portion, and 14 pharmaceuticals were found in both effluent and plasma.
Starting in the mid-1960s, ecologists and toxicologists began to express concern about the potential adverse effects of pharmaceuticals in the water supply, but it wasn’t until a decade later that the presence of pharmaceuticals in water was well documented. Studies in 1975 and 1977 found clofibric acids and salicylic acids at trace concentrations in treated water. Widespread concern about and research into the effect of PPCPs largely started in the early 1990s. Until this time, PPCPs were largely ignored because of their relative solubility and containment in waterways compared to more familiar pollutants like agrochemicals, industrial chemicals, and industrial waste and byproducts.
Since then, a great deal of attention has been directed to the ecological and physiological risk associated with pharmaceutical compounds and their metabolites in water and the environment. In the last decade, most research in this area has focused on steroid hormones and antibiotics. There is concern that steroid hormones may act as endocrine disruptors. Some research suggests that concentrations of ethinylestradiol, an estrogen used in oral contraceptive medications and one of the most commonly prescribed pharmaceuticals, can cause endocrine disruption in aquatic and amphibian wildlife in concentrations as low as 1 ng/L.
- What is the effect of exposure to low levels of PPCPs over time?
- What is the effect of exposure to mixtures of chemicals?
- Are the effects acute (short-term) or chronic (long-term)?
- Are certain populations, such as the elderly, very young, or immuno-compromised, more vulnerable to the effects of these compounds?
- What is the effect of PPCPs on bacterial, fungal, and aquatic life?
- Are the levels of antibiotics in the aquatic environment sufficient to promote antibiotic resistance?
- What is the effect of exposure to steroid hormones on animal and human populations?
Pharmacoenvironmentology is an extension of pharmacovigilance as it deals specifically with the environmental and ecological effects of drugs given at therapeutic doses. Pharmacologists with this particular expertise (known as a pharmacoenvironmentologist) become a necessary component of any team assessing different aspects of drug safety in the environment. We must look at the effects of drugs not only in medical practice, but also at its environmental effects. Any good clinical trial should look at the impact of particular drugs on the environment. Things we need to address in pharmacoenvironmentology are drugs and their exact concentration in different parts of the environment.
Pharmacovigilance is a new branch of science, which was born in 1960 after the incidence of the thalidomide disaster. Thalidomide is a teratogen and caused horrific birth abnormalities. The thalidomide disaster lead to the present day approach to drug safety and adverse event reporting.
According to the EPA, pharamacovigilance is science aiming to capture any adverse effects of pharmaceuticals in humans after use. However, ecopharmacovigilance is the science, and activities concerning detection, assessment, understanding, and prevention of adverse effects of pharmaceuticals in the environment which affect humans and other animal species. There has been a growing focus among scientists about the impact of drugs on the environment. In recent years, we have been able to see human pharmaceuticals that are being detected in the environment which most are typically found on surface water.
The importance of ecopharmacovigilance is to monitor adverse effects of pharmaceuticals on humans through environmental exposure. Due to this relatively new field of science, researchers are continuously developing and understanding the impacts of pharmaceuticals in the environment and its risk on human and animal exposure. Environmental risk assessment is a regulatory requirement in the launch of any new drug. This precaution has become a necessary step towards the understanding and prevention of adverse effects of pharmaceutical residue in the environment. It is important to note that pharmaceuticals enter the environment from the excretion of drugs after human use, hospitals, and improper disposal of unused drugs from patients.
Ecopharmacology concerns the entry of chemicals or drugs into the environment through any route and at any concentration disturbing the balance of ecology (ecosystem), as a consequence. Ecopharmacology is a broad term that includes studies of “PPCPs” irrespective of doses and route of entry into environment.
The geology of a karst aquifer area assists with the movement of PPCPs from the surface to the ground water. Relatively soluble bedrock creates sinkholes, caves and sinking streams into which surface water easily flows, with minimal filtering. Since 25% of the population get their drinking water from karst aquifers, this affects a large number of people. A 2016 study of karst aquifers in southwest Illinois found that 89% of water samples had one or more PPCP measured. Triclocarban (an antimicrobial) was the most frequently detected PPCP, with gemfibrozil (a cardiovascular drug) the second most frequently detected. Other PPCPs detected were trimethoprim, naproxen, carbamazepine, caffeine, sulfamethoxazole, and fluoxetine. The data suggests that septic tank effluent is a probable source of PPCPs.
Fate of pharmaceuticals in sewage treatment plants
Sewage treatment plants (STP) work with physical, chemical, and biological processes to remove nutrients and contaminants from waste water. Usually the STP is equipped with an initial mechanical separation of solid particles (cotton buds, cloth, hygiene articles etc.) appearing in the incoming water. Following this there may be filters separating finer particles either occurring in the incoming water or developing as a consequence of chemical treatment of the water with flocculating agents.
Many STPs also include one or several steps of biological treatment. By stimulating the activity of various strains of microorganisms physically their activity may be promoted to degrade the organic content of the sewage by up to 90% or more. In certain cases more advanced techniques are used as well. The today most commonly used advanced treatment steps especially in terms of micropollutants are
- membranes (which may be used instead of the biological treatment),
- activated carbon (powdered or granulated),
- UV treatment,
- treatment with ferrate and
- sandfiltration (which is sometimes added as a last step after the aforementioned).
- Removal by physical absorption processes: This technique is one of the most common techniques and involves using absorption to remove trace pollutants from water. The most common absorption materials are carbon-based, such as activated carbon, graphene, and carbon nanotubules. Removal of PPCPs by these compounds depends on the physiochemical properties of the pollutant such as the charge and polarity. Thus, the efficiency of these techniques varies greatly by compound.
- Removal by biological degradation processes: Microbial degradation is another important method of removing PPCPs from wastewater. The bacteria may be one species (pure culture) or many species (mixed culture). Mixed cultures can be added to activated sludge and are generally easier to achieve than pure cultures. Activated sludge is commonly used in waste water treatment plants. Microbial degradation is beneficial because it is low cost. However, many areas of the environment have low quantities of the degraders. Techniques such as bioaugmentation and biological acclimation can be used to increase the bacterial population of the desired bacterial species. Bacteriophage can also be used to adjust bacterial populations.
- Removal by chemical advanced oxidation processes: Advanced oxidation processes (AOPs) such as ozone/UV, hydrogen peroxide/UV, Fenton and Fenton-like oxidation, gamma radiolysis and sonolysis, and electrochemical oxidation. Ozone is one of the most efficient methods of removal of PPCPs with efficiencies more than 90%. Fenton oxidation is commonly used to treat industrial wastewater. Ultraviolet treatment disrupts chemical bonds via photolysis.
- Removal by combined chemical and biological methods: Chemical methods are generally used first, then biological methods can be used to break down the intermediaries.
PPCPs are difficult to remove from wastewater with conventional methods. Some research shows the concentration of such substances is even higher in water leaving the plant than water entering the plant. Many factors including environmental pH, seasonal variation, and biological properties affect the ability of a STP to remove PPCPs.
A 2013 study of a drinking water treatment plant, found that of 30 PPCPs measured at both the source water and the drinking water locations, 76% of PPCPs were removed, on average, in the water treatment plant. Ozonation was found to be an efficient treatment process for the removal of many PPCPs. However, there are some PPCPs that were not removed, such as DEET used as mosquito spray, nonylphenol which is a surfactant used in detergents, the antibiotic erythromycin, and the herbicide atrazine.
Several research projects are running to optimize the use of advanced sewage treatment techniques under different conditions. The advanced techniques will increase the costs for the sewage treatment substantially. In a European cooperation project between 2008 and 2012 in comparison 4 hospital waste water treatment facilities were developed in Switzerland, Germany, The Netherlands and Luxembourg to investigate the elimination rates of concentrated waste water with pharmaceutical “cocktails” by using different and combined advanced treatment technologies. Especially the German STP at Marienhospital Gelsenkirchen showed the effects of a combination of membranes, ozone, powdered activated carbon and sand filtration. But even a maximum of installed technologies could not eliminate 100% of all substances and especially radiocontrast agents are nearly impossible to eliminate. The investigations showed that depending on the installed technologies the treatment costs for such a hospital treatment facility may be up to 5.50 € per m2. Other studies and comparisons expect the treatment costs to increase up to 10%, mainly due to energy demand. It is therefore important to define best available technique before extensive infrastructure investments are introduced on a wide basis.
The fate of incoming pharmaceutical residues in the STP is unpredictable. Some substances seem to be more or less completely eliminated, while others pass the different steps in the STP unaffected. There is no systematic knowledge at hand to predict how and why this happens.
Pharmaceutical residues that have been conjugated (bound to a bile acid) before being excreted from the patients may undergo de-conjugation in the STP, yielding higher levels of free pharmaceutical substance in the outlet from the STP than in its incoming water. Some pharmaceuticals with large sales volumes have not been detected in the incoming water to the STP, indicating that complete metabolism and degradation must have occurred already in the patient or during the transport of sewage from the household to the STP.
In terms of rules and regulations, “There are no federal regulations limiting the levels of pharmaceuticals in wastewater or drinking water”, according to the United States Environmental Protection Agency. Three birth controls substances and one antibiotic were added to the pharmaceuticals contaminant candidate list (CCL 3). The EPA states that they are 8 pharmaceuticals that are classified as hazardous waste. Out of 3000 pharmaceuticals the EPA has only evaluated 100 of them leaving numerous of unscreened compounds in the water.” In 2008, EPA proposed an amendment to the Universal Waste Rule to address pharmaceutical wastes.” However, no action on the Rule has occurred since the hearing in the U.S. senate in 2009”.
The Clean Water Act (CWA), Safe drinking water act (SDWA), and the Universal Waste Rule (UWR): due little to protect the American population from pharmaceutical contamination in waterways. The EPA has the ability to implement governmental regulations to insure that the public has access to water that is free of pharmaceutical pollution however, no laws have been enacted even though “ the U.S. Government Accountability Office (GAO) reports that some research has demonstrated potential impact on human health from exposure to pharmaceuticals found in drinking water, such as antibiotics and EE2 substances that interfere with human hormone development”.
The EPA and other governmental agencies are not focused on this issue. They are not demanding any changes or regulations for Pharmaceutical pollution. They did not review the 3000 Pharmaceutical substances to determine their effect on human health. There are no long term studies or health assessments created to examine how this affects us or the environment.
80% of pills in the world are packed with blister packaging, which is the most convenient type for several reasons. Blister packs have two main components, the “lid” and the “blister” (cavity). Lid is mainly manufactured with aluminum (Al) and paper. The Cavity consists of polyvinyl chloride (PVC), polypropylene (PP), polyester (PET) or aluminum (Al). If users employ proper disposal methods, all these materials can be recycled and the harmful effects to the environment can be minimized. However, a problem arises with the improper disposal either by burning or disposing as normal household waste.
Burning of blister packs directly causes air pollution by the combustion products of polypropylene ([C3H6]n), polyester ([C10H8O4]n), and polyvinyl chloride ([CH2CHCl]n). The combustion reactions and products of these chemicals are mentioned below.
[C3H6]n + 9n/2 O2 → 3n CO2 +3n H2O
[C10H8O4]n + 10n O2 → 10n CO2 +4n H2O
[CH2CHCl]n + 2n O2 → n CO2 + n H2O + n HCl + n CO
Even though polypropylene and polyester is harmful to the environment, the most toxic effect is due to the combustion of polyvinyl chloride since it produces hydrochloric acid (HCl) which is an irritant in the lower and upper respiratory tract that can cause adverse to human beings.
The disposal of blister packs as normal waste, will forbid recycling process and eventually accumulate in soil or water, which will result soil and water pollution since bio-degradation processes of compounds like PVC, PP and PET are very slow. As a result, ecologically damaging effects like disturbances of the habitats and movements can be seen. Ingestion by the animals, affect the secretion of gastric enzymes and steroid hormones that can decrease the feeding stimuli and may also cause problems in reproduction. At low pH, aluminum can increase its solubility according to the following equation. As a result, the negative effects of both aquatic and terrestrial ecosystems can be generated.
By employing proper disposal methods, all manufacturing materials of blister packs like PP, PE, PVC and Al can be recycled and the adverse effects to the environment can be minimized. Even though, the synthesis of these polymers relatively simple, the recycling process can be very complex since the blister packs contain metals and polymers together.
As the first step of recycling, separation of Al and Polymers using the hydrometallurgical method which uses hydrochloric acid (HCl) can be incorporated. Then PVC can be recycled by using mechanical or chemical methods. The most recent trend is to use biodegradable, eco-friendly “bio plastics” which are also called as biopolymers such as derivatives of starch, cellulose, protein, chitin and xylan for pharmaceutical packaging, to reduce the hostile effects to the environment.
Nail polish remover
Nail polish remover has the ability to enter bodies of water and soil after entering landfills or by precipitation, such as rain or snow. However, due to acetone's high volatility, most of it that enters the bodies of water and soil will evaporate again and re-enter the atmosphere. Not all of the acetone molecules will evaporate again, and so, when acetone remains in the bodies of water or soil, a reaction will occur. Nail polish remover evaporates easily because acetone's intermolecular forces are weak. An acetone molecule can't attract other acetone molecules easily because its hydrogens are not slightly positive. The only force that holds acetone molecules together is its permanent dipoles which are weaker than hydrogen bonds.
Since nail polish remover is a solvent, it will dissolve in water. When acetone dissolves in water, it hydrogen bonds with water. The more nail polish remover that enters the hydrosphere will increase the concentration of acetone and then increase the concentration of the solution created when acetone and water bonds. If enough nail polish remover is disposed, it can reach the lethal dose level for aquatic life.
Nail polish remover can also enter the lithosphere by landfills and by precipitation. However, it will not bind to the soil. Microorganisms in the soil will decompose acetone. The consequence of microorganisms decomposing acetone is the risk it has to cause oxygen depletion in bodies of water. The more acetone readily available for microorganism decomposition leads to more microorganisms reproduced and thus oxygen depletion because more microorganisms use up the available oxygen.
When nail polish remover evaporates, acetone enters the atmosphere in the gaseous phase. In the gaseous phase, acetone can undergo photolysis and breakdown into carbon monoxide, methane, and ethane. When temperatures are between 100 - 350 degrees Celsius, the following mechanism occurs:
(CH3)2CO + hv → CH3 + CH3CO
CH3CO → CH3+ CO
CH3+ (CH3)2CO → CH4 + CH2COCH3
2CH3 → C2H6
A second pathway that nail polish remover can enter in the atmosphere is reacting with hydroxyl radicals. When acetone reacts with hydroxyl radicals, its main product is methylglyoxal. Methylglyoxal is an organic compound that is a by-product of many metabolic pathways. It is an intermediate precursor for many advanced glycation end-products, that are formed for diseases such as diabetes or neurodegenerative diseases. The following reaction occurs:
(CH3)2CO + ·OH → CH3C(O)OH + ·CH3
CH3C(O)OH + ·CH3→ CH3C(O)COH + 3H+
- Drug pollution
- Plastic particle water pollution
- Environmental impact of silver nanoparticles
- Environmental persistent pharmaceutical pollutant
- Wang, Jianlong; Wang, Shizong (2016). "Removal of pharmaceuticals and personal care products (PPCPs) from wastewater: A review". Journal of Environmental Management. 182: 620–640. doi:10.1016/j.jenvman.2016.07.049. PMID 27552641.
- Doerr-MacEwen NA, Haight ME (November 2006). "Expert stakeholders' views on the management of human pharmaceuticals in the environment". Environ Manage. 38 (5): 853–66. doi:10.1007/s00267-005-0306-z. PMID 16955232.
- Pharmaceuticals in drinking-water. World Health Organization. Geneva, Switzerland: World Health Organization. 2012. ISBN 9789241502085. OCLC 806494582.
- Donn J. (2009). Tons of Released Drugs Taint U.S. Water. AP.
- EPA,OIG, US. "Report: EPA Inaction in Identifying Hazardous Waste Pharmaceuticals May Result in Unsafe Disposal | US EPA". US EPA. Retrieved 2018-03-30.
- BIO Intelligence Service (2013), Study on the environmental risks of medicinal products, Final Report prepared for Executive Agency for Health and Consumers
- "National Take Back Initiative". Office of Diversion Control, United States Drug Enforcement Administration. Retrieved 04/05/2011. Check date values in:
- "Long Battle for State Drug Take-Back Program Must Continue". The Olympian. 2011-03-13. Retrieved 04/05/2011. Check date values in:
- "Proper Disposal of Prescription Drugs" (PDF). U.S. Office of National Drug Policy. October 2009. Archived from the original (PDF) on 2010-03-31.
- Siegrist, H., Ternes, T.A., Joss, A., (2004) Scrutinizing Pharmaceuticals and Personal Care Products in Wastewater Treatment Journal of Environmental Science & Technology,38 392A-399A
- "EU project noPILLS in waters, final report 2015" (PDF). Retrieved 10 September 2017.
- "Origins and Fate of PPCPs in the Environment" (PDF). Pharmaceuticals and Personal Care Products. EPA, National Exposure Research Laboratory. March 2006.
- Tong, A.Y.; Peake, B.; Braund, R. (2011). "Disposal practices for unused medications around the world". Environment International. 37 (1): 292–298. doi:10.1016/j.envint.2010.10.002. PMID 20970194.
- EU project report summary "Pharmaceutical Input and Elimination from Local Sources", 2012
- "Pharmaceuticals and Personal Care Products". Washington, D.C.: U.S. Environmental Protection Agency (EPA). 2012. Retrieved 2015-07-23.
- Buxton, H.T.; Kolpin, D.W. (June 2002). "Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Streams". USGS Fact Sheet FS-027-02. Reston, VA: U.S. Geological Survey.
- "Pharmaceutical and Personal Care Products in Drinking Water Supplies." The Groundwater Foundation. Accessed 19 April 2009.
- Hernando, M.D.; Mezcua, M.; Fernandez-Alba, A.R.; Barcelo, D. (2006). "Environmental Risk Assessment of Pharmaceutical Residues in Wastewater Effluents, Surface Waters and Sediments". Talanta. 69 (2): 334–342. doi:10.1016/j.talanta.2005.09.037. PMID 18970571.
- Jiang, Jheng-Jie; Lee, Chon-Lin; Fang, Meng-Der; et al. (15 December 2014). "Impacts of Emerging Contaminants on Surrounding Aquatic Environment from a Youth Festival". Environmental Science & Technology. 49 (2): 792–799. doi:10.1021/es503944e. PMID 25495157. Lay summary – Pharmaceutical Processing (15 January 2015).
- Papenfuss, Mary (25 May 2018). "Mussels In Waters Off Seattle Test Positive For Opioids". Huffington Post. Retrieved 26 May 2018.
- Daughton, C.G. (2008). Pharmaceuticals as Environmental Pollutants: the Ramifications for Human Exposure. International Encyclopedia of Public Health. 5. pp. 66–122. doi:10.1016/b978-012373960-5.00403-2. ISBN 9780123739605.
- "Pharmaceuticals and personal care products in drinking water." American Water Works Association. Accessed 20 April 2009.
- Snyder, Shane (November 2010). "Pharmaceuticals in the Water Environment" (PDF). Association of Metropolitan Water Agencies: 38 – via American Chemical Society.
- Daughton, C.G. (2008). Pharmaceuticals as Environmental Pollutants: the Ramifications for Human Exposure. International Encyclopedia of Public Health. 5. pp. 66–102. doi:10.1016/b978-012373960-5.00403-2. ISBN 9780123739605.
- Hernando, M.D.; Mezcua, M.; Fernández-Alba, AR.; Barceló, D. (2006). "Environmental Risk Assessment of Pharmaceutical Residues in Wastewater Effluents, Surface Waters and Sediments". Talanta. 69 (2): 334–342. doi:10.1016/j.talanta.2005.09.037. PMID 18970571.
- Segura, P.A.; Francois, M.; Gagnon, C.; Sauve, S. (May 2005). "Review of the Occurrence of Anti-infectives in Contaminated Wastewaters and Natural and Drinking Waters". Environmental Health Perspectives. 117 (5): 675–684. doi:10.1289/ehp.11776. PMC 2685827
. PMID 19479007.
- Modolo, J.R.; Giuffrida, R.; de M. Lopes, C.R. (July 2003). "Antimicrobial Susceptibility of 51 Campylobacter Strains Isolated From Diarrheic and Diarrhea-Free Dogs". Arquivos do Instituto Biológic. 70 (3): 283–286.
- Cook, Bellis (2001). "Knowing the risk: relationships between behaviour and health knowledge. Public Health 115, 54-61". Public Health.
- Nordlund,, A.M. (2003). "Effects of values, problem awareness, and personal norm on willingness to reduce personal car use". J. Environment Psychol.
- Bhati, Itishri (Dec 2013). "Greener Route to Prevent Pharmaceutical Pollution" (PDF). International Journal of Pharmaceutical and Chemical Sciences. 2 (4): 7 – via IJPCS Online.
- Srivastava, Bhavana (2014-05-25). "Drug disposal and environmental concern". Journal of Drug Discovery and Therapeutics. 2 (17). ISSN 2320-4230.
- "Pharmaceuticals and Personal Care Products in the Environment." Washington State University. Accessed 20 April 2009.
- Siegrist, H., Ternes, T.A., Joss, A., (2004) Scrutinizing Pharmaceuticals and Personal Care Products in Wastewater Treatment Journal of Environmental Science & Technology,38 392A-399A
- Zheng, W., Yates, S.R., Bradford, S.A. ( 2007) Analysis of Steroid Hormones in a Typical Dairy Waste Disposal System Journal of Environmental Science & Technology, 42, 530-535
- Fick, Jerker (2009). "Therapeutic Levels of Levonorgestrel Detected in Blood Plasma of Fish: Results from Screening Rainbow Trout Exposed to Treated Sewagae Effluents". Evniron. Sci. Technol.
- Snyder, S.; Westerhoff, P.; Yoon, Y.; Sedlak, D. (2003). "Pharmaceuticals, Personal Care Products, and Endocrine Disruptors in Water: Implications for the Water Industry". Environmental Engineering Science. 20 (5).
- "Chemicals from Pharmaceuticals and Personal Care Products." Water Encyclopedia. Accessed 20 April 2009.
- "Pharmaceuticals and Personal Care Products: An Emerging Issue." The Groudwater Foundation. Accessed 20 April 2009.
- Rahman, Syed Ziaur; Khan, Rahat Ali; Gupta, Varun; Uddin, Misbah (2007-07-24). "Pharmacoenvironmentology – a component of pharmacovigilance". Environmental Health. 6: 20. doi:10.1186/1476-069x-6-20. ISSN 1476-069X. PMC 1947975
. PMID 17650313.
- Medhi, Bikash; Sewal, RakeshK (2012-09-01). "Ecopharmacovigilance: An issue urgently to be addressed". Indian Journal of Pharmacology. 44 (5): 547–9. doi:10.4103/0253-7613.100363. PMC 3480781
. PMID 23112410.
- Dally, Ann (1998). "Thalidomide: was the tragedy preventable?". The Lancet. 351 (9110): 1197–1199. doi:10.1016/s0140-6736(97)09038-7. PMID 9643709.
- Sue Ruhoy, Ilene; Daughton, Christian G. (2008). "Beyond the medicine cabinet: An analysis of where and why medications accumulate". Environment International. 34 (8): 1157–1169. doi:10.1016/j.envint.2008.05.002. PMID 18571238.
- Hashemi, Zahra (2008). "Addendum: Terminologies related to Drug Safety". In Rahman SZ, Shahid M & Gupta A. An Introduction to Environmental Pharmacology (1st ed.). Aligarh: Ibn Sina Academy of Medieval Medicine and Sciences. pp. 257–259. ISBN 978-81-906070-4-9.
- Rahman, SZ; Khan, RA; Gupta, V; Uddin, Misbah (July 2007). "Pharmacoenvironmentology–A Component of Pharmacovigilance". Environmental Health. 6 (20): 20. doi:10.1186/1476-069X-6-20. PMC 1947975
. PMID 17650313.
- Dodgen, L.K.; Kelly, W.R.; Panno, S.V.; Taylor, S.J.; Armstrong, D.L.; Wiles, K.N.; Zhang, Y.; Zheng, W. (2017). "Characterizing pharmaceutical, personal care product, and hormone contamination in a karst aquifer of southwestern Illinois, USA, using water quality and stream flow parameters". Science of the Total Environment. 578: 281–289. doi:10.1016/j.scitotenv.2016.10.103. PMID 27836351.
- Padhye, Lokesh P.; Yao, Hong; Kung'u, Francis T.; Huang, Ching-Hua (2014). "Year-long evaluation on the occurrence and fate of pharmaceuticals, personal care products, and endocrine disrupting chemicals in an urban drinking water treatment plant". Water Research. 51: 266–276. doi:10.1016/j.watres.2013.10.070. PMID 24262763.
- "The PILLS Project". www.pills-project.eu. Retrieved 10 September 2017.
- EGLV Emschergenossenschaft/ Lippeverband (24 February 2015). "noPILLS Emschergenossenschaft Gelsenkirchen (Marienhospital)". Retrieved 10 September 2017 – via YouTube.
- "EU project PILLS summary" (PDF). Retrieved 10 September 2017.
- "Report of the German Federal Environment Agency" (PDF). Retrieved 10 September 2017.
- Pilchik, Ron (November 2000). "Pharmaceutical Blister Packaging, Part I: Rationale and Materials". Pharmaceutical Technology: 68–78.
- Huggett, Clayton; Levin, Barbara C. (1987-09-01). "Toxicity of the pyrolysis and combustion products of poly(vinyl chlorides): A literature assessment" (Submitted manuscript). Fire and Materials. 11 (3): 131–142. doi:10.1002/fam.810110303. ISSN 1099-1018.
- Webb, Hayden K.; Arnott, Jaimys; Crawford, Russell J.; Ivanova, Elena P. (2012-12-28). "Plastic Degradation and Its Environmental Implications with Special Reference to Poly(ethylene terephthalate)". Polymers. 5 (1): 1–18. doi:10.3390/polym5010001.
- Rosseland, B. O.; Eldhuset, T. D.; Staurnes, M. (1990-03-01). "Environmental effects of aluminium". Environmental Geochemistry and Health. 12 (1–2): 17–27. doi:10.1007/BF01734045. ISSN 0269-4042. PMID 24202562.
- Wang, Chongqing; Wang, Hui; Liu, Younian (2015-09-01). "Separation of aluminum and plastic by metallurgy method for recycling waste pharmaceutical blisters". Journal of Cleaner Production. 102: 378–383. doi:10.1016/j.jclepro.2015.04.067.
- Singh, Anupama; Sharma, Pramod Kumar, Malviya, Rishabha; (15 September 2015). "Eco Friendly Pharmaceutical Packaging Material". World Applied Sciences Journal: 1703–1716. ISSN 1818-4952.
- Sadat-Shojai, Mehdi; Bakhshandeh, Gholam-Reza (2011-04-01). "Recycling of PVC wastes". Polymer Degradation and Stability. 96 (4): 404–415. doi:10.1016/j.polymdegradstab.2010.12.001.
- "Intermolecular Forces and Solutions". employees.csbsju.edu. Retrieved 2016-12-06.
- "Toxilogical Profile for Acetone" (PDF). www.atsdr.cdc.gov. Agency for Toxic Substances and Disease Registry. May 1994.
- Cundall, R. B.; Davies, A. S. (1 January 1966). "The Mechanism of the Gas Phase Photolysis of Acetone". Proceedings of the Royal Society of London. Series A, Mathematical and Physical Sciences. 290 (1423): 563–582. doi:10.1098/rspa.1966.0071. JSTOR 2415445.
- Darwent, B. deB.; Allard, M. J.; Hartman, M. F.; Lange, L. J. (1960-12-01). "The Photolysis of Acetone". The Journal of Physical Chemistry. 64 (12): 1847–1850. doi:10.1021/j100841a010. ISSN 0022-3654.
- "Toxicological Profile for Acetone - Potential for Human Exposure" (PDF).
- Kümmerer, K. (2010). "Pharmaceuticals in the Environment". Annual Review of Environment and Resources. 35: 57–75. doi:10.1146/annurev-environ-052809-161223.
- Kumar, R. R.; Lee, J. T.; Cho, J. Y. (2012). "Fate, occurrence, and toxicity of veterinary antibiotics in environment". Journal of the Korean Society for Applied Biological Chemistry. 55 (6): 701. doi:10.1007/s13765-012-2220-4.
- "How to Dispose of Unused Medicines". Consumer Updates. U.S. Food and Drug Administration. 2015-06-04.