Dimetindene

Dimetindene
Clinical data
Trade names Fenistil
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral, topical
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.024.622
Chemical and physical data
Formula C20H24N2
Molar mass 292.418 g/mol
3D model (JSmol)
Chirality Racemic mixture
  (verify)

Dimetindene[1] (trade name Fenistil; other name dimethindene maleate) is an antiallergic drug. Dimetindene is an antihistamine/anticholinergic that is a selective H1 antagonist.[2] As dimetindene only minimally passes across the blood-brain barrier,[3] it is classified as a second generation antihistamine.

Clinical use

Dimetindene is used orally and topically as an antipruritic.[4] It is used topically to treat skin irritations, such as insect bites. Dimentidene is also administered orally to treat allergies, such as hay fever. Unlike first generation antihistamines, it causes only minimal drowsiness.

References

  1. https://www.wikigenes.org/e/chem/e/21855.html
  2. https://www.drugs.com/international/dimetindene.html
  3. https://www.wikigenes.org/e/ref/e/1353628.html
  4. Wexler, L. (1962). "A Clinical Evaluation of Dimethindene". Current Therapeutic Research, Clinical and Experimental. 4: 306–9. PMID 14006402.
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