Clinical data
Trade names Fertodur, Menopax, Ondonid, Ondogyne, Sexovid, others
Synonyms F-6066; H-3452; ICI-48213; bis(p-Acetoxyphenyl)-
AHFS/ International Drug Names
Routes of
By mouth
Drug class Selective estrogen receptor modulator; Progonadotropin
ATC code
CAS Number
PubChem CID
ECHA InfoCard 100.018.264
Chemical and physical data
Formula C23H24O4
Molar mass 364.434 g/mol
3D model (JSmol)

Cyclofenil (INN, USAN, BAN) (brand names Fertodur, Menopax, Ondonid, Ondogyne, Sexovid, others) is a selective estrogen receptor modulator (SERM) used as a gonadotropin stimulant which is or has been marketed in Europe, South Korea, Mexico, and Brazil, among other countries.[1][2][3]

Cyclofenil was first introduced in 1970 under the brand name Ondogyne in France.[4] Subsequently, it was introduced under the brand names Sexovid in Japan in 1972, Ondonvid in the United Kingdom in 1972, and Fertodur in West Germany in 1972 and Italy in 1974.[4] It was also marketed as Sexovid in Sweden, Neoclym in Italy, and Klofenil in Turkey.[4]

Cyclofenil was studied in the 1970s as an agent to induce ovulation in infertile women.[5] It was then investigated as a possible treatment for scleroderma in the 1980s, but was found to be ineffective.[6] Later study of its efficacy in treating Raynaud's phenomenon in people with scleroderma also found no statistically significant benefit.[7]


  1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 329–. ISBN 978-1-4757-2085-3.
  2. Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 284–. ISBN 978-3-88763-075-1.
  4. 1 2 3 William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 1162–. ISBN 978-0-8155-1856-3.
  5. Ruíz-Velasco V, Rosas-Arceo J, Matute MM (1979). "Chemical inducers of ovulation: comparative results". Int J Fertil. 24: 61–4. PMID 37182.
  6. Torres MA, Furst DE (February 1990). "Treatment of generalized systemic sclerosis". Rheum Dis Clin North Am. 16 (1): 217–41. PMID 2406809.
  7. Pope J, Fenlon D, Thompson A, et al. (2000). Pope J, ed. "Cyclofenil for Raynaud's phenomenon in progressive systemic sclerosis". Cochrane Database Syst Rev (2): CD000955. doi:10.1002/14651858.CD000955. PMID 10796397.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.