Clinical data
Trade names Etumina, Etumine, Entumin, Etomine, Entumine
AHFS/ International Drug Names
Routes of
Oral, Intravenous and Intramuscular
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
CAS Number
PubChem CID
ECHA InfoCard 100.016.512
Chemical and physical data
Formula C18H18ClN3S
Molar mass 343.87 g/mol
3D model (JSmol)
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Clotiapine (Entumine) is an atypical antipsychotic[1] of the dibenzothiazepine chemical class.[2] It was first introduced in a few European countries (namely, Belgium, Italy, Spain and Switzerland), Argentina, Taiwan and Israel in 1970.[3]

Some sources regard clotiapine as a typical antipsychotic rather than atypical due to its high incidence of extrapyramidal side effects compared to the atypicals like clozapine and quetiapine, to which it is structurally related.[4] Despite its profile of a relatively high incidence of extrapyramidal side effects it has demonstrated efficacy in treatment-resistant individuals with schizophrenia according to a number of psychiatrists with clinical experience with it, some weak clinical evidence supports this view too.[3][4][5] A systematic review compared clotiapine with other antipsychotic drugs:

Clotiapine compared to other antipsychotic drugs for acute psychotic illnesses[6]
There was no evidence to support or refute the use of clotiapine in preference to other antipsychotic drug treatments for management of people with acute psychotic illness.[6]


  1. Seminara, G.; Trassari, V.; Prestifilippo, N.; Chiavetta, R.; Calandra, C. (1993). "Atypical tricyclic neuroleptics for treatment of schizophrenia. Clothiapine and clozapine". Minerva Psichiatrica. 34 (2): 95–99. PMID 8105359.
  2. Schmutz, J.; Künzle, F.; Hunziker, F.; Gauch, R. (1967). "Über in 11-Stellung amino-substituierte Dibenzo[b,f]-1, 4-thiazepine und -oxazepine. 9. Mitteilung über siebengliedrige Heterocyclen". Helvetica Chimica Acta. 50: 245–254. doi:10.1002/hlca.19670500131.
  3. 1 2 Lokshin, P; Kotler, M; Belmaker, RH (September 1997). "Clotiapine: Another forgotten treasure in psychiatry?". European Neuropsychopharmacology. 7 (Suppl 2): S217. doi:10.1016/S0924-977X(97)88712-3.
  4. 1 2 Geller, V; Gorzaltsan, I; Shleifer, T; Belmaker, RH; Bersudsky, Y (December 2005). "Clotiapine compared with chlorpromazine in chronic schizophrenia". Schizophrenia Research. 80 (2–3): 343–347. doi:10.1016/j.schres.2005.07.007. PMID 16126373.
  5. Van Wyk, AJ; Marais, GF (August 1971). "chlorpromazine, clotiapine and thioridazine--a comparative clinical trial on Bantu psychotic patients" (PDF). South African Medical Journal. 45 (34): 945–947. PMID 4939661.
  6. 1 2 Berk, M; Rathbone, J; Mandriota-Carpenter, S (2004). "Clotiapine for acute psychotic illnesses". Cochrane Database of Systematic Reviews. 4 (4): CD002304.pub2. doi:10.1002/14651858.CD002304.pub2. PMID 15495032.

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