Climbazole

Climbazole
Clinical data
Routes of
administration
topical
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
ECHA InfoCard 100.048.870
Chemical and physical data
Formula C15H17ClN2O2
Molar mass 292.76
3D model (JSmol)
Chirality Racemic mixture
 NY (what is this?)  (verify)

Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff[2] and eczema. Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role in the pathogenesis of dandruff.[2] Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole.

Indications and formulations

It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan.

Side effects

May cause localized irritation of the skin with symptoms including redness, rashes and itching.

References

  1. Chemical Properties of Climbazole Archived 2007-11-13 at the Wayback Machine.
  2. 1 2 Wigger-Alberti, W; Kluge, K; Elsner, P (2001). "Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema". Praxis. 90 (33): 1346–9. PMID 11534318.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.