5,7-Dihydroxyflavone; NP-005901; Galangin flavanone
3D model (JSmol)
|Molar mass||254.24 g·mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Chrysin, also called 5,7-dihydroxyflavone, is a flavone found in honey, propolis, honeycomb, the passion flowers, Passiflora caerulea and Passiflora incarnata, and in Oroxylum indicum. Commercially, it is extracted from blue passion flowers. Chrysin is an ingredient in dietary supplements, but its efficacy and safety have not been adequately defined.
Present in carrots and flowers of some plants, chrysin is a dihydroxyflavone, a type of flavonoid. It has been isolated from honey, propolis, honeycomb, and the passion flowers, Passiflora caerulea and Passiflora incarnata, and from Oroxylum indicum. It is also found in chamomile and in the mushroom, Pleurotus ostreatus.
Although chrysin is an ingredient in dietary supplements and topical medications intended to improve physical performance or treat various clinical conditions, its safety, efficacy, and history for use in compounding remain undefined.
Preliminary determinations from oral consumption of chrysin indicate a daily amount of 0.5 to 3 g is safe, although other reviews describe that its safety is not yet adequately evaluated. It is not recommended for use as an ingredient in topical medications.
As of 2016, there is no evidence for chrysin in human clinical applications and its use for compounding of therapeutic agents is not recommended. Research showed that orally administered chrysin does not have clinical activity as an aromatase inhibitor.
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