Chloroxine

Chloroxine
Clinical data
Trade names Capitrol
Synonyms cloroxinum, kloroxin, chlorquinol, dichlorchinolinolum, halquinol(s)
AHFS/Drugs.com Micromedex Detailed Consumer Information
ATC code
  • none
Legal status
Legal status
Identifiers
PubChem CID
ChemSpider
UNII
ChEMBL
ECHA InfoCard 100.011.144
Chemical and physical data
Formula C9H5Cl2NO
Molar mass 214 g/mol
3D model (JSmol)

Chloroxine (trade name Capitrol; Kloroxin, Dichlorchinolinol, chlorquinol, halquinol(s)); Latin cloroxinum, dichlorchinolinolum) is an antibacterial drug.[1] Oral formulations (under trade name such as Endiaron[2]) are used in infectious diarrhea, disorders of the intestinal microflora (e.g. after antibiotic treatment), giardiasis, inflammatory bowel disease. It is also useful for dandruff and seborrheic dermatitis.,[3] as used in shampoos (Capitrol) and dermal creams like (Valpeda, Triaderm).

Mechanism of action

Chloroxine has bacteriostatic, fungistatic, and antiprotozoal properties. It is effective against Streptococci, Staphylococci, Candida, Candida albicans, Shigella, and Trichomonads.

Adverse effects

Rarely occurs, but may cause nausea and vomiting associated with oral administration. It may also cause skin irritation.

Pregnancy and lactation

The FDA lists chloroxine in Pregnancy Category C (risk cannot be ruled out) because no pregnancy studies on the medication have been performed with animals or humans. For this reason, use of chloroxine oral or topical during pregnancy or when breast-feeding is not recommended.[4]

History

Chloroxine was first prepared in 1888 by A. Hebebrand.

References


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.