Ceftizoxime

Ceftizoxime
Clinical data
Trade names Cefizox
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a684043
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.210.846
Chemical and physical data
Formula C13H13N5O5S2
Molar mass 383.405 g/mol

Ceftizoxime is a third-generation cephalosporin available for parenteral administration. Unlike other third-generation cephalosporins, the whole C-3 side chain in ceftizoxime has been removed to prevent deactivation by hydrolytic enzymes. It rather resembles cefotaxime in its properties, but is not subject to metabolism. It was removed from the US Market in 2007.

Synthesis

Injectable third generation cephalosporin antibiotic related to cefotaxime, q.v. Exhibits broad spectrum activity and resistance to β-lactamase hydrolysis.

References

  1. T. Takaya et al., DE 2810922; eidem, U.S. Patent 4,427,674 (1978, 1984 both to Fujisawa).


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