|Chemical and physical data|
|Molar mass||365.47 g/mol|
|3D model (JSmol)|
Caroverine (Spasmium, Tinnitin, Tinnex) is a muscle-relaxing drug used in Austria and Switzerland to relieve spasms in smooth muscles (which include intestines, arteries, and other organs), and the use in those countries was extended to aid with cerebrovascular diseases there, and eventually to treat tinnitus. It is also used to treat tinnitus in India.
Chemically, it is a quinoxalinedione and is available in both a base and hydrochloric acid forms.
It was discovered in Austria in the 1950s and was developed by Austrian company Phafag AG.
An intravenous formulation was tested in a single-blinded study in tinnitus that published in 1997 and had positive results; an effort to replicate those results failed to show any effect, and more people had their condition worsen than experienced benefit. Pilot studies using a spray formulation for tinnitus published in 2005.
As of 2016 it had been studied in a small clinical trial in people with loss of the sense of smell.
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