CHRNA5

CHRNA5
Identifiers
AliasesCHRNA5, LNCR2, cholinergic receptor nicotinic alpha 5 subunit
External IDsMGI: 87889 HomoloGene: 55485 GeneCards: CHRNA5
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q25.1Start78,565,520 bp[1]
End78,595,269 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1138

110835

Ensembl

ENSG00000169684

ENSMUSG00000035594

UniProt

P30532

Q2MKA5

RefSeq (mRNA)

NM_000745
NM_001307945

NM_176844

RefSeq (protein)

NP_000736
NP_001294874

NP_789814

Location (UCSC)Chr 15: 78.57 – 78.6 MbChr 9: 54.98 – 55.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-5, also known as nAChRα5, is a protein that in humans is encoded by the CHRNA5 gene.[5][6] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

Function

Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits.[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
  1. The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000169684 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035594 - Ensembl, May 2017
  3. "Human PubMed Reference:".
  4. "Mouse PubMed Reference:".
  5. Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–82. doi:10.1016/0888-7543(91)90253-B. PMID 2004777.
  6. 1 2 "Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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