Under the Seleucids, Amyzon was one of the cities in the Chrysaorian League of Carian cities that lasted at least until 203 BCE, when Antiochus III confirmed the privileges of Amyzon. The League had a form of reciprocal citizenship whereby a citizen of a member city was entitled to certain rights and privileges in any other member city.
The city was dismissed by Strabo as a mere peripolion ('suburb' or 'township') of Alabanda; Amyzon was mentioned by Pliny, Ptolemy and Hierocles. In the wars among the successors of Alexander, in the 3rd century BCE, the city allied with the less immediately threatening power, first with the Ptolemies, then with the Seleucids. In the second city it concluded an alliance with Heracleia under Latmos. On one occasion it sent a delegation to the oracle of Apollo at Clarus. The few coins identified as from the mint at Amyzon are Hellenistic and Imperial Roman.
A stretch of the city wall stands 6 m high (in fact, the terrace wall of the shrine); inside it are a few ruined and unidentifiable buildings, as well as a row of a dozen large vaulted underground chambers, apparently storerooms. There are also Byzantine structures. Outside the city a series of ruined terraces mark the site of the Doric temple of Artemis, which dates from the time of the Hecatomnids: an architrave block has been found bearing a dedication by Idrieus. Numerous other inscriptions abound.
- Philetus fl451
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- Franz Großmann (Grossmann) (17 Jun 1844 Appointed – 5 May 1852 Died)
- Ireneus Frederic Baraga (29 Jul 1853 Appointed – 9 Jan 1857 Appointed, Bishop of Sault Sainte Marie, Michigan)
- Józef Twarowski (3 Aug 1857 Appointed – 19 Jan 1868 Died)
- Ildefonso Giovanni Battista Borgna, (24 May 1871 Appointed – 14 Dec 1886 Appointed, Titular Archbishop of Marcianopolis)
- Heinrich Feiten (20 Sep 1887 Appointed – 17 Feb 1892 Died)
- Ignacio Ibáñez, (4 May 1893 Appointed – 14 Oct 1893 Died)
- Pio Gaetano Secondo Stella (22 Dec 1893 Appointed – 21 Sep 1927 Died)
- Gabriele Perlo, (22 Dec 1927 Appointed – 26 Sep 1948 Died)
- Charles Dauvin, (9 Dec 1948 Appointed – 28 Dec 1948 Died)
- Baltasar Álvarez Restrepo † (7 May 1949 Appointed – 18 Dec 1952 Appointed, Bishop of Pereira)
- Luigi Cicuttini (6 Apr 1953 Appointed – 30 Nov 1956 Appointed, Bishop of Città di Castello)
- Antonin Fishta, (17 Dec 1956 Appointed – 12 Jan 1980 Died)
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