Amidorphin

Amidorphin
Identifiers
3D model (JSmol)
ChemSpider
Properties
C131H200N30O43S2
Molar mass 2947.29 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Amidorphin is an endogenous, C-terminally amidated, opioid peptide generated as a cleavage product of proenkephalin A that is widely distributed in the mammalian brain, with particularly high concentrations found in the adrenal medulla, posterior pituitary, and striatum.[1][2] In some brain areas, amidorphin is extensively further reduced into smaller fragments, such as the non-opioid peptide amidorphin-(8-26) which lacks the N-terminal [Met]enkephalin sequence of amidorphin; accordingly, [Met]enkephalin may also be a cleavage product of amidorphin.[3]

See also

References

  1. Seizinger BR; Liebisch DC; Gramsch C; et al. (1985). "Isolation and structure of a novel C-terminally amidated opioid peptide, amidorphin, from bovine adrenal medulla". Nature. 313 (5997): 57–9. doi:10.1038/313057a0. PMID 3965972.
  2. Liebisch DC, Seizinger BR, Michael G, Herz A (November 1985). "Novel opioid peptide amidorphin: characterization and distribution of amidorphin-like immunoreactivity in bovine, ovine, and porcine brain, pituitary, and adrenal medulla". Journal of Neurochemistry. 45 (5): 1495–503. doi:10.1111/j.1471-4159.1985.tb07218.x. PMID 4045460.
  3. Liebisch DC, Weber E, Kosicka B, Gramsch C, Herz A, Seizinger BR (March 1986). "Isolation and structure of a C-terminally amidated nonopioid peptide, amidorphin-(8-26), from bovine striatum: a major product of proenkephalin in brain but not in adrenal medulla". Proceedings of the National Academy of Sciences of the United States of America. 83 (6): 1936–40. doi:10.1073/pnas.83.6.1936. PMC 323199. PMID 3456613.


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