Legal status
Legal status
CAS Number
PubChem CID
Chemical and physical data
Formula C20H21FN4O2
Molar mass 368.40 g/mol
3D model (JSmol)

AB-FUBINACA is a drug that acts as a potent agonist for the cannabinoid receptors, with Ki values of 0.9 nM at CB1 and 23.2 nM at CB2 and EC50 values of 1.8 nM at CB1 and 3.2 nM at CB2.[1][2][3] It was originally developed by Pfizer in 2009 as an analgesic medication[4] but was never pursued for human use. In 2012, it was discovered as an ingredient in synthetic cannabis blends in Japan,[5] along with a related compound AB-PINACA, which had not previously been reported.

Its use has been linked to hospitalizations and deaths.[6][7]


It was designated as a Schedule I controlled substance in the United States in January 2014.[8]

It is an Anlage II controlled substance in Germany as of November 2014.[9]

It is a controlled substance in China as of October 2015.[10]

Mass Overdoses in New Haven, Connecticut 2018

On August 15th, 2018, 70 people within the city of New Haven, Connecticut started overdosing near Yale University campus.[11] By the end of the week, the total number of overdosed had risen to over 100 people needing transport to local emergency rooms. Three men were arrested, charged as drug dealers selling synthetic cannabis, which was laced with the drug AB-FUBINACA. Police originally said the drugs were laced with fentanyl.[12] [13]

New Haven Police arrested John Parker, 53, on charges of possession with intent to sell after finding 32 bags of "K2", or "spice," in his house. He was also charged in connection with a February police operation. NHPD said Felix Melendez, 37, was also arrested charged with possession of a controlled substance. Melendez was on probation for a prior conviction of selling K2 at the park. Almost all of the overdoses occurred on the New Haven Green, a large downtown park that is heavily traveled and very popular with the homeless population. The 3rd Suspect that was arrested by Federal Authorities has not been named. [14]

There have been no deaths associated with the overdoses. However, several victims are in critical or life-threatening condition. [15]

See also


  1. Samuel D Banister; Michael Moir; Jordyn Stuart; Richard C Kevin; Katie E Wood; Mitchell Longworth; Shane M Wilkinson; Corinne Beinat; Alxendra S Buchanan; Michelle Glass; Mark Connor; Iain S McGregor; Michael Kassiou (July 2015). "The pharmacology of indole and indazole synthetic cannabinoid designer drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA and 5F-ADBICA". ACS Chemical Neuroscience. 6 (9): 1546–1559. doi:10.1021/acschemneuro.5b00112. PMID 26134475.
  2. Hsin-Hung Chen; Aybike Dip; Mostafa Ahmed; Michael L. Tan; Jeffrey P. Walterscheid; Hua Sun; Ba-Bie Teng; Ashraf Mozayani (April 2016). "Detection and Characterization of the Effect of AB-FUBINACA and its Metabolites in a Rat Model". Journal of Cellular Biochemistry. 117 (4): 1033–1043. doi:10.1002/jcb.25421. PMID 26517302.
  3. Svante Vikingsson; Henrik Gréen; Linda Brinkhagen; Shahzabe Mukhtar; Martin Josefsson (November 2015). "Identification of AB-FUBINACA metabolites in authentic urine samples suitable as urinary markers of drug intake using liquid chromatography quadrupole tandem time of flight mass spectrometry". Drug Testing and Analysis. 8 (9): 950–6. doi:10.1002/dta.1896. PMID 26560240.
  4. Buchler IP et al., INDAZOLE DERIVATIVES. WO 2009/106982
  5. Uchiyama, N.; Matsuda, S.; Wakana, D.; Kikura-Hanajiri, R.; Goda, Y. (January 2013). "New cannabimimetic indazole derivatives, N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA) identified as designer drugs in illegal products". Forensic Toxicology. 31 (1): 93–100. doi:10.1007/s11419-012-0171-4.
  6. Jordan Trecki; Roy R. Gerona; Michael D. Schwartz (July 2015). "Synthetic Cannabinoid–Related Illnesses and Deaths". New England Journal of Medicine. 373 (2): 103–107. doi:10.1056/NEJMp1505328. PMID 26154784.
  7. Janez Klavž; Maksimiljan Gorenjak; Martin Marinšek (August 2016). "Suicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC". Forensic Science International. 265: 121–124. doi:10.1016/j.forsciint.2016.01.018. PMID 26890319.
  8. "Schedules of Controlled Substances: Temporary Placement of Four Synthetic Cannabinoids Into Schedule I". Drug Enforcement Administration, Department of Justice. 10 January 2014. Retrieved 21 July 2015.
  9. "Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz - BtMG) Anlage II (zu § 1 Abs. 1) (verkehrsfähige, aber nicht verschreibungsfähige Betäubungsmittel)" (in German). Retrieved 22 June 2015.
  10. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015.
  11. https://www.nytimes.com/2018/08/15/nyregion/new-haven-overdose-k2.html
  12. "Police Arrest Third Suspect In New Haven Synthetic Marijuana Overdose Case". NPR. 17 August 2018. Retrieved 20 August 2018.
  13. "Dozens Overdose In Connecticut Park On Tainted Synthetic Marijuana". NPR. 16 August 2018. Retrieved 20 August 2018.
  14. "New Haven police make arrest after more than 100 K2 overdose calls". CNN. 18 August 2018. Retrieved 18 August 2018.
  15. "Police Arrest Third Suspect In New Haven Synthetic Marijuana Overdose Case". NPR. 17 August 2018. Retrieved 20 August 2018.

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